Poh Churn K, Hardy Peter A, Liao Zhijie, Huang Zhongping, Clark William R, Gao Dayong
Department of Mechanical Engineering, University of Kentucky, Lexington, KY 40506-0108, USA.
ASAIO J. 2003 Jul-Aug;49(4):440-8.
Blood side and dialysate side flow distributions play an important role in determining the optimal use of dialysis membrane in hemodialyzers for the removal of uremic solutes. In this article, we used two nonintrusive magnetic resonance imaging (MRI) techniques called the two-dimensional phase contrast (2DPC) and two-dimensional Fourier transform (2DFT) velocity imaging techniques to (1) study the effect of space yarns on the dialysate side flow distribution, (2) investigate the effect of flow baffle on the dialysate side flow distribution, and (3) characterize the blood side and dialysate side flow profiles of hemodialyzers with flow rates ranging from 200 to 1000 ml/min. We investigated two types of hollow fiber hemodialyzers: hemodialyzers A (with spacer yarns) and B (without spacer yarns). We used a 3 mmol cupric sulfate solution as the compartmental fluid and imaged five transverse cross sections of these hemodialyzers. The hemodialyzer with spacer yarns had a more uniform dialysate side spatial flow distribution than that without spacer yarns. In addition, the design of flow baffle in these hemodialyzers can be further improved to promote uniform dialysate side flow distribution, and the blood side flow had a fully developed laminar flow profile. Our experimental results showed that these velocity imaging techniques provide an innovative, nonintrusive tool for characterizing flow distribution in hemodialyzers.
血液侧和透析液侧的流动分布在确定血液透析器中透析膜用于清除尿毒症溶质的最佳使用方式方面起着重要作用。在本文中，我们使用了两种非侵入性磁共振成像（MRI）技术，即二维相位对比（2DPC）和二维傅里叶变换（2DFT）速度成像技术，来（1）研究间隔纱线对透析液侧流动分布的影响，（2）研究导流板对透析液侧流动分布的影响，以及（3）表征流速范围为200至1000 ml/min的血液透析器的血液侧和透析液侧流动剖面。我们研究了两种类型的中空纤维血液透析器：血液透析器A（带有间隔纱线）和B（不带有间隔纱线）。我们使用3 mmol的硫酸铜溶液作为隔室流体，并对这些血液透析器的五个横向横截面进行成像。带有间隔纱线的血液透析器的透析液侧空间流动分布比不带有间隔纱线的更均匀。此外，这些血液透析器中导流板的设计可以进一步改进以促进透析液侧流动分布均匀，并且血液侧流动具有充分发展的层流剖面。我们的实验结果表明，这些速度成像技术为表征血液透析器中的流动分布提供了一种创新的、非侵入性的工具。
