Department of Gastroenterology, University of Sao Paulo, Sao Paulo, Brazil.
Pancreatology. 2009;9(5):687-93. doi: 10.1159/000199438. Epub 2009 Aug 14.
Severe acute pancreatitis is associated with high morbidity and mortality rates. At the present time, no specific therapy has been shown to be uniformly effective in reducing morbidity and mortality in this disease. The aim of this study was to determine the effects of pentoxifylline on the pancreatic and systemic inflammatory process, pancreatic infection, and mortality rate in severe acute pancreatitis in rats.
One hundred and twenty male Wistar rats were divided into 3 groups: sham, pancreatitis, and pentoxifylline (acute pancreatitis induction plus administration of 25 mg/kg pentoxifylline). Inflammatory response was measured by histological studies, inflammatory cytokine production (IL-6, IL-10, and TNF-alpha), and mortality rate. Pancreatic infection was evaluated by bacterial cultures expressed in colony-forming units per gram.
Pentoxifylline-treated animals had a statistically significant reduction of inflammatory cytokine levels, pancreatic histological damage, occurrence of bacterial translocation and pancreatic infection (p < 0.05), associated with a significant reduction in mortality rate.
Pentoxifylline administration in this experimental model of acute pancreatitis reduces local and systemic inflammatory responses and decreases the pancreatic infection and the mortality rate.
本研究旨在确定己酮可可碱对大鼠重症急性胰腺炎胰腺和全身炎症过程、胰腺感染和死亡率的影响。
将 120 只雄性 Wistar 大鼠分为 3 组：假手术组、胰腺炎组和己酮可可碱组（急性胰腺炎诱导加 25mg/kg 己酮可可碱治疗）。通过组织学研究、炎症细胞因子（IL-6、IL-10 和 TNF-α）产生和死亡率来衡量炎症反应。通过每克菌落形成单位表示的细菌培养来评估胰腺感染。
与假手术组相比，己酮可可碱治疗组的炎症细胞因子水平、胰腺组织学损伤、细菌易位和胰腺感染的发生率均显著降低（p<0.05），死亡率也显著降低。
在急性胰腺炎的实验模型中，己酮可可碱的给药可降低局部和全身炎症反应，并降低胰腺感染和死亡率。
