Lev-Gur M, Rodriguez L J, Smith K D, Steinberger E
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York.
Int J Fertil. 1990 Jan-Feb;35(1):51-7.
Charts of 206 consecutive pregnancies occurring in couples seen because of infertility were analyzed in an attempt to identify factors, apparent at the time of conception, which may impose risks on pregnancy outcome. These factors were compared in 34 spontaneous abortions and 172 full-term pregnancies. Although the mean age was similar in both groups, women 35 years or older had a significantly higher incidence of spontaneous abortion than younger women. Menstrual history, gravidity, and parity and incidence of previous induced abortions were not different in the spontaneous abortion and term groups. Data collected from basal body temperature charts suggested a slightly higher risk for spontaneous abortion in women with previous anovulatory cycles. The mean follicular phase in the conception cycle was 16 days in both groups. However, a twofold increase in abortion rate was noticed in conceptions with follicular phases shorter than 12 days or longer than 16 days, in comparison with those with follicular phases of 13-15 days' duration. The mean daily temperature increment in the early luteal phase was the same in both groups. No relation between sperm count or motility and spontaneous abortion was observed. Different treatment modalities during the conception cycle had no effect on abortion rate, except for a trend toward lower spontaneous abortion incidence in women who received only prednisone.
对因不孕前来就诊的夫妇连续发生的206次妊娠图表进行了分析，以试图确定受孕时明显存在的、可能对妊娠结局构成风险的因素。在34例自然流产和172例足月妊娠中对这些因素进行了比较。虽然两组的平均年龄相似，但35岁及以上的女性自然流产发生率明显高于年轻女性。自然流产组和足月妊娠组在月经史、妊娠次数、产次及既往人工流产发生率方面并无差异。从基础体温图表收集的数据表明，既往有无排卵周期的女性自然流产风险略高。两组受孕周期的平均卵泡期均为16天。然而，与卵泡期持续时间为13 - 15天的受孕相比，卵泡期短于12天或长于16天的受孕流产率增加了两倍。两组黄体早期的平均每日体温升高相同。未观察到精子计数或活力与自然流产之间的关系。受孕周期中的不同治疗方式对流产率没有影响，仅接受泼尼松治疗的女性自然流产发生率有降低趋势除外。
