Wang Jim X, Davies Michael J, Norman Robert J
Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, University of Adelaide, The Queen Elizabeth Hospital, Woodville, Australia.
Obes Res. 2002 Jun;10(6):551-4. doi: 10.1038/oby.2002.74.
This study examines the relationship between body mass and the risk of spontaneous abortion in a large cohort of patients who received infertility treatment.
This is a retrospective study using data on pregnancies (n = 2349) achieved after treatment in a tertiary medical center from 1987 to 1999. One pregnancy per subject was included, and the subjects were stratified into five body mass groups based on body mass index (BMI): underweight, <18.5 kg/m(2); normal, 18.5 to 24.9 kg/m(2); overweight, 25 to 29.9 kg/m(2); obese, 30 to 34.9 kg/m(2); and very obese, > or =35 kg/m(2). Logistical regression analysis was used.
The overall incidence of spontaneous abortion was 20% (476 of 2349). The effect of BMI on the risk of spontaneous abortion was significant after adjusting for several independent risk factors. Compared with the reference group (BMI 18.5 to 24.9 kg/m(2)), underweight women had a similar risk of spontaneous abortion, whereas there was progressive increase of risk in overweight, obese, and very obese groups (p < 0.05, p < 0.01, and p < 0.001, respectively).
Of all known risk factors for spontaneous abortion, the control of obesity has great significance because it is noninvasive, potentially modifiable, possibly amenable to low cost, and self-manageable by patients. This study established a positive relationship between BMI and the risk of spontaneous abortion in women who became pregnant after assisted reproductive technology treatment.
本研究在一大群接受不孕症治疗的患者中，探讨体重与自然流产风险之间的关系。
这是一项回顾性研究，使用了1987年至1999年在一家三级医疗中心治疗后成功怀孕的数据（n = 2349）。每位受试者纳入一次怀孕情况，并根据体重指数（BMI）将受试者分为五个体重组：体重过轻，<18.5 kg/m²；正常，18.5至24.9 kg/m²；超重，25至29.9 kg/m²；肥胖，30至34.9 kg/m²；以及极度肥胖，≥35 kg/m²。采用逻辑回归分析。
自然流产的总体发生率为20%（2349例中的476例）。在调整了几个独立风险因素后，BMI对自然流产风险的影响显著。与参照组（BMI 18.5至24.9 kg/m²）相比，体重过轻的女性自然流产风险相似，而超重、肥胖和极度肥胖组的风险则逐渐增加（分别为p < 0.05、p < 0.01和p < 0.001）。
在所有已知的自然流产风险因素中，控制肥胖具有重要意义，因为它是非侵入性的、有可能改变、可能成本低廉且患者可自行管理。本研究在接受辅助生殖技术治疗后怀孕的女性中，确立了BMI与自然流产风险之间的正相关关系。
