穿越细胞：UNC-53 和导航蛋白，细胞骨架调节蛋白家族，在细胞迁移、延伸和运输中具有多种功能。
Navigating the cell: UNC-53 and the navigators, a family of cytoskeletal regulators with multiple roles in cell migration, outgrowth and trafficking.
机构信息
Department of Biology, Trinity Western University, Langley, BC, Canada.
出版信息
Cell Adh Migr. 2009 Oct-Dec;3(4):342-6. doi: 10.4161/cam.3.4.9451. Epub 2009 Oct 3.
Abstract
Changes in cell shape are associated with a variety of processes including cell migration, axon outgrowth, cell division and vesicle trafficking. C. elegans UNC-53 and its vertebrate homologs, the Navigators, are required for the migration of cells and the outgrowth of neuronal processes. The identification of novel molecular interactions and live imaging studies have revealed that UNC-53/NAVs are signal transducers associated with actin filaments, microtubules and intermediate filaments. In addition to modulating cytoskeletal dynamics at the leading edge of migrating or outgrowing cells, both UNC-53 and the navigators are expressed in adult cells, conspicuously those with specialized roles in endocytosis or secretion. Collectively, these results suggest that UNC-53/NAVs may be a central regulator of cytoskeletal dynamics, responsible for integrating signaling cues to multiple components of the cytoskeleton to coordinate rearrangement during cell outgrowth or trafficking.
摘要
细胞形状的变化与多种过程相关，包括细胞迁移、轴突生长、细胞分裂和囊泡运输。秀丽隐杆线虫 UNC-53 及其脊椎动物同源物，导航蛋白，对于细胞迁移和神经元突起的生长是必需的。新的分子相互作用的鉴定和活细胞成像研究表明，UNC-53/导航蛋白是与肌动蛋白丝、微管和中间丝相关的信号转导蛋白。除了调节迁移或生长的细胞前缘的细胞骨架动力学之外，UNC-53 和导航蛋白都在成年细胞中表达，特别是在胞吞或分泌中具有特殊作用的细胞中。总的来说，这些结果表明 UNC-53/导航蛋白可能是细胞骨架动力学的中央调节剂，负责整合信号提示到细胞骨架的多个成分，以协调细胞生长或运输过程中的重排。
相似文献
1
Navigating the cell: UNC-53 and the navigators, a family of cytoskeletal regulators with multiple roles in cell migration, outgrowth and trafficking.穿越细胞：UNC-53 和导航蛋白，细胞骨架调节蛋白家族，在细胞迁移、延伸和运输中具有多种功能。
Cell Adh Migr. 2009 Oct-Dec;3(4):342-6. doi: 10.4161/cam.3.4.9451. Epub 2009 Oct 3.
2
Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans.Abelson 相互作用蛋白-1（ABI-1）与 MRL 衔接蛋白 MIG-10 相互作用，并且在秀丽隐杆线虫的导向细胞迁移和突起生长过程中是必需的。
Dev Biol. 2013 Jan 1;373(1):1-13. doi: 10.1016/j.ydbio.2012.09.017. Epub 2012 Sep 27.
3
The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1.细胞迁移分子UNC-53/NAV2通过ABI-1与ARP2/3复合体相连。
Development. 2009 Feb;136(4):563-74. doi: 10.1242/dev.016816.
4
Axon guidance: asymmetric signaling orients polarized outgrowth.轴突导向：不对称信号传导使极化生长定向。
Trends Cell Biol. 2008 Dec;18(12):597-603. doi: 10.1016/j.tcb.2008.09.005. Epub 2008 Oct 24.
5
The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans.Arp2/3 复合物、UNC-115/abLIM 和 UNC-34/Enabled 调节秀丽隐杆线虫的轴突导向和生长锥丝状伪足形成。
Neural Dev. 2009 Oct 2;4:38. doi: 10.1186/1749-8104-4-38.
6
The actin-binding protein UNC-115/abLIM controls formation of lamellipodia and filopodia and neuronal morphogenesis in Caenorhabditis elegans.肌动蛋白结合蛋白UNC-115/abLIM控制秀丽隐杆线虫中片状伪足和丝状伪足的形成以及神经元形态发生。
Mol Cell Biol. 2005 Jun;25(12):5158-70. doi: 10.1128/MCB.25.12.5158-5170.2005.
7
Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.秀丽隐杆线虫中两种肌动蛋白解聚因子/丝切蛋白亚型在不同肌动蛋白依赖性过程中的特定要求。
J Cell Sci. 2003 May 15;116(Pt 10):2073-85. doi: 10.1242/jcs.00421. Epub 2003 Apr 1.
8
The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans.含短卷曲螺旋结构域的蛋白质UNC-69与UNC-76协同作用，以调节秀丽隐杆线虫的轴突生长和正常突触前组织。
J Biol. 2006;5(4):9. doi: 10.1186/jbiol39. Epub 2006 May 25.
9
Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration.线虫轴突导向和神经元迁移过程中UNC-34 Enabled与Rac GTP酶及NIK激酶MIG-15的相互作用
Genetics. 2006 Feb;172(2):893-913. doi: 10.1534/genetics.105.046359. Epub 2005 Oct 3.
10
RHO-1 and the Rho GEF RHGF-1 interact with UNC-6/Netrin signaling to regulate growth cone protrusion and microtubule organization in Caenorhabditis elegans.RHO-1 和 Rho GEF RHGF-1 与 UNC-6/神经导向因子信号相互作用，调节秀丽隐杆线虫生长锥的突起和微管组织。
PLoS Genet. 2019 Jun 24;15(6):e1007960. doi: 10.1371/journal.pgen.1007960. eCollection 2019 Jun.
引用本文的文献
1
Whole-exome sequencing reveals candidate high-risk susceptibility genes for endometriosis.全外显子组测序揭示子宫内膜异位症的候选高危易感基因。
Hum Genomics. 2023 Oct 3;17(1):88. doi: 10.1186/s40246-023-00538-9.
2
The Neuron Navigators: Structure, function, and evolutionary history.神经元导航蛋白：结构、功能及进化史
Front Mol Neurosci. 2023 Jan 12;15:1099554. doi: 10.3389/fnmol.2022.1099554. eCollection 2022.
3
The +TIP Navigator-1 is an actin-microtubule crosslinker that regulates axonal growth cone motility.TIP 导航器-1 是一种肌动蛋白微管交联剂，可调节轴突生长锥的运动。
J Cell Biol. 2020 Sep 7;219(9). doi: 10.1083/jcb.201905199.
4
Actin-microtubule crosstalk in cell biology.肌动蛋白-微管相互作用在细胞生物学中的作用。
Nat Rev Mol Cell Biol. 2019 Jan;20(1):38-54. doi: 10.1038/s41580-018-0067-1.
5
A Statistically-Oriented Asymmetric Localization (SOAL) Model for Neuronal Outgrowth Patterning by UNC-5 (UNC5) and UNC-40 (DCC) Netrin Receptors.统计导向不对称定位（SOAL）模型，用于 UNC-5（UNC5）和 UNC-40（DCC）轴突导向因子受体对神经元生长模式的调控。
Genetics. 2018 Jan;208(1):245-272. doi: 10.1534/genetics.117.300460. Epub 2017 Nov 1.
6
The unc-53 gene negatively regulates rac GTPases to inhibit unc-5 activity during Distal tip cell migrations in C. elegans.unc-53 基因负调控 rac GTPases，以抑制线虫远端细胞迁移过程中 unc-5 的活性。
Cell Adh Migr. 2018 May 4;12(3):195-203. doi: 10.1080/19336918.2017.1345413. Epub 2017 Oct 26.
7
The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans.秀丽隐杆线虫轴突导向与轴突再生的遗传学
Genetics. 2016 Nov;204(3):849-882. doi: 10.1534/genetics.115.186262.
8
Microtubule plus-end tracking proteins in neuronal development.神经元发育中的微管正端追踪蛋白
Cell Mol Life Sci. 2016 May;73(10):2053-77. doi: 10.1007/s00018-016-2168-3. Epub 2016 Mar 11.
9
Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression.导航蛋白-3是一种细胞迁移调节因子，可能作为乳腺癌进展的抑制因子发挥作用。
EMBO Mol Med. 2015 Mar;7(3):299-314. doi: 10.15252/emmm.201404134.
10
Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity.实验证据表明 UNC-6（神经导向因子）轴突的导向是由 UNC-40（DCC）细胞内生长活性的随机波动引起的。
Biol Open. 2013 Dec 15;2(12):1300-12. doi: 10.1242/bio.20136346.
本文引用的文献
1
Mammalian Navigators are microtubule plus-end tracking proteins that can reorganize the cytoskeleton to induce neurite-like extensions.哺乳动物导航蛋白是微管正端追踪蛋白，可重组细胞骨架以诱导神经突样延伸。
Cell Motil Cytoskeleton. 2009 Oct;66(10):824-38. doi: 10.1002/cm.20370.
2
The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1.细胞迁移分子UNC-53/NAV2通过ABI-1与ARP2/3复合体相连。
Development. 2009 Feb;136(4):563-74. doi: 10.1242/dev.016816.
3
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.ACF7调节细胞骨架-粘着斑动力学和迁移，并具有ATP酶活性。
Cell. 2008 Oct 3;135(1):137-48. doi: 10.1016/j.cell.2008.07.045.
4
The atRA-responsive gene neuron navigator 2 functions in neurite outgrowth and axonal elongation.全反式维甲酸反应性基因神经导航蛋白2在神经突生长和轴突延伸中发挥作用。
Dev Neurobiol. 2008 Nov;68(13):1441-53. doi: 10.1002/dneu.20670.
5
Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic.全基因组分析确定了内吞运输中极性蛋白的普遍需求。
Nat Cell Biol. 2007 Sep;9(9):1066-73. doi: 10.1038/ncb1627. Epub 2007 Aug 19.
6
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation.阿贝尔森相互作用蛋白1（Abi-1）对于树突形态发生和突触形成至关重要。
EMBO J. 2007 Mar 7;26(5):1397-409. doi: 10.1038/sj.emboj.7601569. Epub 2007 Feb 15.
7
Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity.秀丽隐杆线虫神经元的基因表达携带着有关其突触连接性的信息。
PLoS Comput Biol. 2006 Dec 8;2(12):e167. doi: 10.1371/journal.pcbi.0020167.
8
Exo70 interacts with the Arp2/3 complex and regulates cell migration.Exo70与肌动蛋白相关蛋白2/3复合体相互作用并调节细胞迁移。
Nat Cell Biol. 2006 Dec;8(12):1383-8. doi: 10.1038/ncb1505. Epub 2006 Nov 5.
9
Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue.原发性皮肤T细胞淋巴瘤表现出影响人类UNC-53同源物NAV3的缺失或易位。
Cancer Res. 2005 Sep 15;65(18):8101-10. doi: 10.1158/0008-5472.CAN-04-0366.
10
LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction.LL5β：一种在神经肌肉接头处突触富集转录本筛选中鉴定出的突触后分化调节因子。
J Cell Biol. 2005 Apr 25;169(2):355-66. doi: 10.1083/jcb.200411012.
Zotero 插件