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2
The NAV2 homolog Sickie regulates F-actin-mediated axonal growth in Drosophila mushroom body neurons via the non-canonical Rac-Cofilin pathway.NAV2同源物Sickie通过非经典的Rac-丝切蛋白途径调节果蝇蘑菇体神经元中F-肌动蛋白介导的轴突生长。
Development. 2014 Dec;141(24):4716-28. doi: 10.1242/dev.113308. Epub 2014 Nov 19.
3
Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity.实验证据表明 UNC-6（神经导向因子）轴突的导向是由 UNC-40（DCC）细胞内生长活性的随机波动引起的。
Biol Open. 2013 Dec 15;2(12):1300-12. doi: 10.1242/bio.20136346.
4
14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation.14-3-3ε 与 NAV2 相互作用，调节神经突生长和轴突伸长。
Arch Biochem Biophys. 2013 Dec;540(1-2):94-100. doi: 10.1016/j.abb.2013.10.012. Epub 2013 Oct 23.
5
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Wiley Interdiscip Rev Dev Biol. 2012 Jul-Aug;1(4):519-31. doi: 10.1002/wdev.45.
6
Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans.Abelson 相互作用蛋白-1（ABI-1）与 MRL 衔接蛋白 MIG-10 相互作用，并且在秀丽隐杆线虫的导向细胞迁移和突起生长过程中是必需的。
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7
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8
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unc-53 基因负调控 rac GTPases，以抑制线虫远端细胞迁移过程中 unc-5 的活性。

The unc-53 gene negatively regulates rac GTPases to inhibit unc-5 activity during Distal tip cell migrations in C. elegans.

机构信息

a Department of Plant Molecular Biology , University of Delhi South Campus , New Delhi , India.

b Department of Genetics , University of Delhi South Campus , New Delhi , India.

出版信息

Cell Adh Migr. 2018 May 4;12(3):195-203. doi: 10.1080/19336918.2017.1345413. Epub 2017 Oct 26.

DOI:10.1080/19336918.2017.1345413
PMID:28678595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6149439/
Abstract

The unc-53/NAV2 gene encodes for an adaptor protein required for cell migrations along the anteroposterior (AP) axes of C. elegans. This study identifies unc-53 as a novel component of signaling pathways regulating Distal tip cell (DTC) migrations along the AP and dorsoventral (DV) axes. unc-53 negatively regulates and functions downstream of ced-10/Rac pathway genes; ced-10/Rac and mig-2/RhoG, which are required for proper DTC migration. Moreover, unc-53 exhibits genetic interaction with abl-1 and unc-5, the 2 known negative regulators of ced-10/Rac signaling. Our genetic analysis supports the model, where abl-1 negatively regulates unc-53 during DTC migrations and requirement of unc-53 function during both AP and DV DTC migrations could be due to unc-53 mediated regulation of unc-5 activity.

摘要

unc-53/NAV2 基因编码一种衔接蛋白，该蛋白对于线虫的沿前后轴（AP）细胞迁移是必需的。本研究确定 unc-53 是调控沿 AP 和背腹轴（DV）迁移的远端 tip 细胞（DTC）迁移的信号通路的一个新的组成部分。unc-53 负调控并作用于 ced-10/Rac 途径基因下游；ced-10/Rac 和 mig-2/RhoG，它们对于 DTC 的正常迁移是必需的。此外，unc-53 与 abl-1 和 unc-5 表现出遗传相互作用，abl-1 和 unc-5 是 ced-10/Rac 信号的 2 个已知负调控因子。我们的遗传分析支持这样的模型，即在 DTC 迁移过程中，abl-1 负调控 unc-53，而 unc-53 在 AP 和 DV DTC 迁移过程中的功能需求可能是由于 unc-53 介导的 unc-5 活性的调节。