unc-53 基因负调控 rac GTPases，以抑制线虫远端细胞迁移过程中 unc-5 的活性。
The unc-53 gene negatively regulates rac GTPases to inhibit unc-5 activity during Distal tip cell migrations in C. elegans.
机构信息
a Department of Plant Molecular Biology , University of Delhi South Campus , New Delhi , India.
b Department of Genetics , University of Delhi South Campus , New Delhi , India.
出版信息
Cell Adh Migr. 2018 May 4;12(3):195-203. doi: 10.1080/19336918.2017.1345413. Epub 2017 Oct 26.
The unc-53/NAV2 gene encodes for an adaptor protein required for cell migrations along the anteroposterior (AP) axes of C. elegans. This study identifies unc-53 as a novel component of signaling pathways regulating Distal tip cell (DTC) migrations along the AP and dorsoventral (DV) axes. unc-53 negatively regulates and functions downstream of ced-10/Rac pathway genes; ced-10/Rac and mig-2/RhoG, which are required for proper DTC migration. Moreover, unc-53 exhibits genetic interaction with abl-1 and unc-5, the 2 known negative regulators of ced-10/Rac signaling. Our genetic analysis supports the model, where abl-1 negatively regulates unc-53 during DTC migrations and requirement of unc-53 function during both AP and DV DTC migrations could be due to unc-53 mediated regulation of unc-5 activity.
unc-53/NAV2 基因编码一种衔接蛋白，该蛋白对于线虫的沿前后轴（AP）细胞迁移是必需的。本研究确定 unc-53 是调控沿 AP 和背腹轴（DV）迁移的远端 tip 细胞（DTC）迁移的信号通路的一个新的组成部分。unc-53 负调控并作用于 ced-10/Rac 途径基因下游；ced-10/Rac 和 mig-2/RhoG，它们对于 DTC 的正常迁移是必需的。此外，unc-53 与 abl-1 和 unc-5 表现出遗传相互作用，abl-1 和 unc-5 是 ced-10/Rac 信号的 2 个已知负调控因子。我们的遗传分析支持这样的模型，即在 DTC 迁移过程中，abl-1 负调控 unc-53，而 unc-53 在 AP 和 DV DTC 迁移过程中的功能需求可能是由于 unc-53 介导的 unc-5 活性的调节。
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