Zhang Zhang-Jin, Wang Xue-Yi, Tan Qing-Rong, Jin Gui-Xing, Yao Shao-Min
School of Chinese Medicine, University of Hong Kong, Hong Kong, China.
J Nerv Ment Dis. 2009 Aug;197(8):619-22. doi: 10.1097/NMD.0b013e3181b05fd1.
A large proportion of obsessive-compulsive disorder (OCD) patients are refractory to pharmacological and cognitive-behavioral therapy. The aim of this pilot, waitlist-controlled trial was to evaluate the effectiveness of electroacupuncture (EA) as add-on therapy for treatment-resistant OCD. Nineteen patients with treatment-resistant OCD were assigned to EA treatment for 12 sessions (5 sessions per week, n = 10) or waitlist for controls (n = 9) while continuing their current anti-OCD medications. The clinical outcomes were measured using the Yale-Brown Obsessive-Compulsive Scale and the Clinical Global Impression-Severity at baseline and end point. EA additional treatment produced significantly greater improvements at end point compared with the waitlist group in reducing both Yale-Brown Obsessive-Compulsive Scale (10.2 +/- 4.2 vs. 18.8 +/- 7.4, p = 0.004) and Clinical Global Impression-Severity scores (3.0 +/- 1.1 vs. 4.4 +/- 1.1, p = 0.002). As an additional therapy, EA is effective in alleviating OCD symptoms of treatment-resistant patients. A large-scale controlled study is warranted.
很大一部分强迫症（OCD）患者对药物治疗和认知行为疗法无效。这项初步的、等待名单对照试验的目的是评估电针（EA）作为难治性强迫症附加疗法的有效性。19名难治性强迫症患者被分配接受12次EA治疗（每周5次，n = 10）或列入等待名单作为对照（n = 9），同时继续服用他们目前的抗强迫症药物。在基线和终点时，使用耶鲁-布朗强迫症量表和临床总体印象-严重程度来衡量临床结果。与等待名单组相比，EA附加治疗在终点时在降低耶鲁-布朗强迫症量表得分（10.2±4.2对18.8±7.4，p = 0.004）和临床总体印象-严重程度得分（3.0±1.1对4.4±1.1，p = 0.002）方面产生了显著更大的改善。作为一种附加疗法，EA在减轻难治性患者的强迫症症状方面是有效的。有必要进行大规模对照研究。
