慢性肝炎中碳水化合物抗原“唾液酸化路易斯X”的肝细胞表达。一种用于活动性肝坏死炎症的新型组织学标志物。

The hepatocellular expression of a carbohydrate antigen 'sialyl Lewis X' in chronic hepatitis. A novel histological marker for active hepatic necroinflammation.

作者信息

Okada Y, Usumoto R, Muguruma M, Shimoe T, Sunayama T, Yamada G, Yamamoto K, Yamabuki T, Tsuji T

机构信息

First Department of Internal Medicine, Okayama University Medical School, Japan.

出版信息

J Hepatol. 1990 Jan;10(1):1-7. doi: 10.1016/0168-8278(90)90065-y.

DOI:10.1016/0168-8278(90)90065-y

PMID:1968474

Abstract

The hepatocellular expression of the carbohydrate antigen sialyl monomeric Lewis X (SMLex) and sialyl oligomeric Lewis X(SOLex) in chronic hepatitis was examined using specific monoclonal antibodies. Both of these sialyl Lewis X (SLex) antigens were membranously expressed in chronic hepatitis in spite of their absence in normal liver. Although SMLex was detected in mild hepatic inflammation, the expression of SOLex was associated only with moderate to severe necroinflammation. Hepatocellular expression of these antigens increased significantly as histological diagnosis advanced. Chronological observation also showed the change of SLex expression according to the histological change. The present observations suggest that hepatocellular SLex is a novel histological marker with a close correlation to the severity of necroinflammation in chronic hepatitis.

摘要

使用特异性单克隆抗体检测了慢性肝炎中碳水化合物抗原唾液酸化单体路易斯X（SMLex）和唾液酸化低聚路易斯X（SOLex）的肝细胞表达。尽管在正常肝脏中不存在这两种唾液酸化路易斯X（SLex）抗原，但它们在慢性肝炎中均呈膜性表达。虽然在轻度肝炎症中检测到了SMLex，但SOLex的表达仅与中度至重度坏死性炎症相关。随着组织学诊断的进展，这些抗原的肝细胞表达显著增加。时间顺序观察也显示SLex表达随组织学变化而改变。目前的观察结果表明，肝细胞SLex是一种与慢性肝炎坏死性炎症严重程度密切相关的新型组织学标志物。