Bloom S, Heryet A, Fleming K, Chapman R W
Department of Gastroenterology, John Radcliffe Hospital, Oxford.
Gut. 1993 Jul;34(7):977-83. doi: 10.1136/gut.34.7.977.
The distribution of carbohydrate antigens of the ABO, Lewis, and Kell systems was examined in biliary and colonic epithelial of 11 patients with primary sclerosing cholangitis (PSC) using a panel of 11 monoclonal antibodies. Controls consisted of 27 liver biopsy specimens (11 normal, six alcoholic liver disease, five extrahepatic obstruction, and five primary biliary cirrhosis) and 24 colonic biopsy specimens (six normal, four Crohn's disease, and 14 ulcerative colitis). There was inappropriate staining with anti-A (four of six, 66%) and anti-B (nine of 11, 81%) in biliary epithelium of PSC patients compared with normal and disease controls. Expression of Lewis antigens was increased in patients with cholestatic liver disease. Ninety one per cent of PSC patients showed a similar pattern of inappropriate staining by anti-A and anti-B antibodies in colonic epithelium compared with 33% of normal and 42% of inflammatory bowel disease controls. There is inappropriate expression of A and B carbohydrate antigens in biliary and colonic epithelium in PSC. Whether these oncofetal antigens are implicated in the pathogenesis of this condition is discussed.
使用一组11种单克隆抗体，对11例原发性硬化性胆管炎（PSC）患者的胆管和结肠上皮细胞中ABO、Lewis和Kell系统碳水化合物抗原的分布进行了检测。对照组包括27份肝活检标本（11份正常、6份酒精性肝病、5份肝外梗阻和5份原发性胆汁性肝硬化）以及24份结肠活检标本（6份正常、4份克罗恩病和14份溃疡性结肠炎）。与正常和疾病对照组相比，PSC患者胆管上皮细胞中抗A（6例中的4例，66%）和抗B（11例中的9例，81%）染色异常。胆汁淤积性肝病患者Lewis抗原的表达增加。与33% 的正常对照组和42% 的炎症性肠病对照组相比，91% 的PSC患者结肠上皮细胞中抗A和抗B抗体染色异常模式相似。PSC患者的胆管和结肠上皮细胞中存在A和B碳水化合物抗原的异常表达。文中讨论了这些癌胚抗原是否与该疾病的发病机制有关。
