Moskophidis D, Fang L, Gossmann J, Drjupin R, Löhler J, Bruns M, Lehmann-Grube F
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Hamburg, Federal Republic of Germany.
J Immunol. 1990 Mar 1;144(5):1926-34.
We had previously shown that the local lymphocytic choriomeningitis virus-induced delayed-type hypersensitivity (DTH) reaction in mice consists of two well delineated phases that are mediated by CD8+ and CD4+ T lymphocytes, respectively. These findings have been confirmed and extended by showing that the first CD8+ cell-dependent part of the response was enhanced by either the presence of CD4+ cells or systemic treatment with IL-2 and that it developed in the absence of detectable numbers of mononuclear phagocytes, whereas the later CD4+ cell part required monocytes or related elements. Furthermore, in the DTH reaction that was elicited with noninfectious viral Ag in mice previously immunized by infection, only the CD4+ cells participated. Thus, the two phases of the lymphocytic choriomeningitis-viral DTH reaction are principally different, which has to be taken into account when trying to assess the relevance of DTH during this virus infection.
我们之前已经表明，小鼠局部淋巴细胞性脉络丛脑膜炎病毒诱导的迟发型超敏反应（DTH）由两个界限分明的阶段组成，分别由CD8 +和CD4 + T淋巴细胞介导。这些发现已得到证实并得到扩展，结果显示，反应的第一个CD8 +细胞依赖性部分可通过CD4 +细胞的存在或IL-2的全身治疗而增强，并且在没有可检测数量的单核吞噬细胞的情况下发生，而后期的CD4 +细胞部分则需要单核细胞或相关成分。此外，在用先前通过感染免疫的小鼠中的非感染性病毒抗原引发的DTH反应中，只有CD4 +细胞参与。因此，淋巴细胞性脉络丛脑膜炎病毒DTH反应的两个阶段本质上是不同的，在试图评估该病毒感染期间DTH的相关性时必须考虑到这一点。
