Cavalheiro Norma de Paula, De La Rosa Abel, Elagin Slava, Tengan Fátima Mitiko, Araújo Evaldo Stanislau Affonso de, Barone Antonio Alci
Hepatitis Laboratory, Infectious Diseases Departament, Medical School/USP, University of São Paulo, Rua Paraguassu 174/141, São Paulo, SP, Brazil.
Rev Soc Bras Med Trop. 2009 May-Jun;42(3):239-44. doi: 10.1590/s0037-86822009000300001.
The role of sexual or intrafamilial transmission of hepatitis C is controversial. A phylogenetic analysis was performed on the non-structural region 5B of the hepatitis C virus (NS5B-HCV). High percentages of homology (mean of 98.3%) were shown between the couples. Twenty (83.3%) of the 24 men but only two of the women (8.3%) reported having had sexually transmitted diseases during their lives. The risk factors for HCV acquisition were blood transfusion (10 couples), use of illegal injected drugs (17), use of inhalants (15), acupuncture (5) and tattoos (5). The shared use of personal hygiene items included toothbrushes between six couples (25%), razor blades between 16 (66.7%), nail clippers between 21 (87.5%) and manicure pliers between 14 (58.3%). The high degree of similarity of the hepatitis C virus genome supports the hypothesis of hepatitis C virus transmission between these couples. The shared use of personal hygiene items suggests the possibility of intrafamilial transmission of infection.
丙型肝炎的性传播或家庭内传播作用存在争议。对丙型肝炎病毒的非结构区5B（NS5B - HCV）进行了系统发育分析。夫妻之间显示出高百分比的同源性（平均98.3%）。24名男性中有20名（83.3%）报告一生中曾患性传播疾病，而女性中只有两名（8.3%）有此报告。感染丙型肝炎病毒的危险因素包括输血（10对夫妻）、使用非法注射毒品（17例）、使用吸入剂（15例）、针灸（5例）和纹身（5例）。共用个人卫生用品的情况包括，6对夫妻（25%）共用牙刷，16对（66.7%）共用剃须刀片，21对（87.5%）共用指甲刀，14对（58.3%）共用修甲钳。丙型肝炎病毒基因组的高度相似性支持了这些夫妻之间丙型肝炎病毒传播的假说。共用个人卫生用品表明存在家庭内感染传播的可能性。
