Centre for the Cellular Basis of Behaviour and MRC Centre for Neurodegeneration Research, The James Black Centre, Institute of Psychiatry, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Genes Nutr. 2009 Dec;4(4):271-82. doi: 10.1007/s12263-009-0134-5. Epub 2009 Aug 15.
Research over the last 5 years has firmly established that learning and memory abilities, as well as mood, can be influenced by diet, although the mechanisms by which diet modulates mental health are not well understood. One of the brain structures associated with learning and memory, as well as mood, is the hippocampus. Interestingly, the hippocampus is one of the two structures in the adult brain where the formation of newborn neurons, or neurogenesis, persists. The level of neurogenesis in the adult hippocampus has been linked directly to cognition and mood. Therefore, modulation of adult hippocampal neurogenesis (AHN) by diet emerges as a possible mechanism by which nutrition impacts on mental health. In this study, we give an overview of the mechanisms and functional implications of AHN and summarize recent findings regarding the modulation of AHN by diet.
在过去的 5 年中，研究已经明确，饮食可以影响学习和记忆能力以及情绪，但饮食调节心理健康的机制尚不清楚。与学习和记忆以及情绪相关的大脑结构之一是海马体。有趣的是，海马体是成人大脑中两个能够持续形成新神经元（神经发生）的结构之一。成年海马体中的神经发生水平与认知和情绪直接相关。因此，饮食对成年海马体神经发生（AHN）的调节成为营养影响心理健康的一种可能机制。在本研究中，我们概述了 AHN 的机制和功能意义，并总结了最近关于饮食对 AHN 调节的发现。
