Institute of Psychiatry, Centre for the Cellular Basis of Behaviour, The James Black Centre, King's College London, London, UK.
Br Med Bull. 2012 Sep;103(1):89-114. doi: 10.1093/bmb/lds021. Epub 2012 Jul 24.
Over the last 8 years, emerging studies bridging the gap between nutrition and mental health have resolutely established that learning and memory abilities as well as mood can be influenced by diet. However, the mechanisms by which diet modulates mental health are still not well understood. Sources of data In this article, a review of the literature was conducted using PubMed to identify studies that provide functional implications of adult hippocampal neurogenesis (AHN) and its modulation by diet.
One of the brain structures associated with learning and memory as well as mood is the hippocampus. Importantly, the hippocampus is one of the two structures in the adult brain where the formation of newborn neurons, or neurogenesis, persists.
The exact roles of these newborn neurons in learning, memory formation and mood regulation remain elusive.
Nevertheless, there has been accumulating evidence linking cognition and mood to neurogenesis occurring in the adult hippocampus. Therefore, modulation of AHN by diet emerges as a possible mechanism by which nutrition impacts on mental health.
This area of investigation is new and needs attention because a better understanding of the neurological mechanisms by which nutrition affect mental health may lead to novel dietary approaches for disease prevention, healthier ageing and discovery of new therapeutic targets for mental illnesses.
在过去的 8 年中，营养与心理健康之间的新兴研究坚决确立了学习和记忆能力以及情绪可以受到饮食的影响。然而，饮食调节心理健康的机制仍未得到很好的理解。
在本文中，使用 PubMed 对文献进行了综述，以确定提供成年海马神经发生（AHN）及其饮食调节的功能意义的研究。
与学习、记忆和情绪相关的大脑结构之一是海马体。重要的是，海马体是成年大脑中两个形成新神经元（神经发生）持续存在的结构之一。
这些新生神经元在学习、记忆形成和情绪调节中的确切作用仍不清楚。
尽管如此，越来越多的证据将认知和情绪与成年海马体中的神经发生联系起来。因此，饮食对 AHN 的调节成为营养影响心理健康的一种可能机制。
这一研究领域是新的，需要关注，因为更好地了解营养影响心理健康的神经机制可能会导致针对疾病预防、更健康的衰老和精神疾病新治疗靶点的新饮食方法。
