金属疗法：药物设计中的新策略。
Metallotherapeutics: novel strategies in drug design.
作者信息
Hocharoen Lalintip, Cowan James A
机构信息
Evans Laboratory of Chemistry, Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA.
出版信息
Chemistry. 2009 Sep 7;15(35):8670-6. doi: 10.1002/chem.200900821.
Abstract
A new paradigm for drug activity is presented, which includes both recognition and subsequent irreversible inactivation of therapeutic targets. Application to both RNA and protein biomolecules has been demonstrated. In contrast to RNA targets that are subject to strand scission chemistry mediated by ribose H-atom abstraction, proteins appear to be inactivated either through oxidative damage to amino acid side chains around the enzyme active site, or by backbone hydrolysis.
摘要
提出了一种药物活性的新范式，其中包括对治疗靶点的识别以及随后的不可逆失活。已证明该范式适用于RNA和蛋白质生物分子。与通过核糖氢原子提取介导的链断裂化学作用的RNA靶点不同，蛋白质似乎是通过对酶活性位点周围氨基酸侧链的氧化损伤或主链水解而失活的。
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