Song Yan, Bai Weiliang, Ji Wenyue
Department of Otolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110004, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Apr;23(8):357-8, 363.
Observe the therapeutic effect of low dose Roxithromycin in treating chronic sinusitis and further discuss the mechanism of Roxithromycin facile endothelial cell apoptosis.
All 47 patients who suffer chronic sinusitis at out-patient clinic from 2006. 10 to 2008. 03 were administered low dose Roxithromycin. Follow up all the patients and get polypi at 3-month and 6-month. AO/EB was employed to detect the apoptosis of endothelial cell.
At 3-month and 6-month the improvement of ventilation are 37.25 +/- 12.21, 63.15 +/- 22.78; Decrease of nasal discharge are 42.12 +/- 13.56, 74.45 +/- 28.79; alleviation of headache are 18.98 +/- 7. 66, 34.47 +/- 14.11; Improvement of olfactory are 21.23 +/- 8.41, 38.18 +/- 16.54; Apoptotic index are (39.54 +/- 6.86)% and (62.34 +/- 8.67)%, which are significantly different (P<0.05).
Low dose Roxithromycin has good long term curative effect in treating chronic sinusitis. Low dose Roxithromycin can greatly urge the apoptosis of endothelial cell.
观察小剂量罗红霉素治疗慢性鼻窦炎的疗效，并进一步探讨罗红霉素促进内皮细胞凋亡的机制。
选取2006年10月至2008年3月在门诊就诊的47例慢性鼻窦炎患者，给予小剂量罗红霉素治疗。对所有患者进行随访，在3个月和6个月时获取息肉。采用AO/EB法检测内皮细胞凋亡情况。
3个月和6个月时通气改善情况分别为37.25±12.21、63.15±22.78；流涕减少情况分别为42.12±13.56、74.45±28.79；头痛缓解情况分别为18.98±7.66、34.47±14.11；嗅觉改善情况分别为21.23±8.41、38.18±16.54；凋亡指数分别为(39.54±6.86)%和(62.34±8.67)%，差异有统计学意义(P<0.05)。
小剂量罗红霉素治疗慢性鼻窦炎有良好的远期疗效。小剂量罗红霉素可显著促进内皮细胞凋亡。
