Kimura N, Nishioka K, Nishizaki K, Ogawa T, Naitou Y, Masuda Y
Department of Otolaryngology, Hiroshima City Hospital, Japan.
Acta Med Okayama. 1997 Feb;51(1):33-7. doi: 10.18926/AMO/30802.
We studied the clinical efficacy of roxithromycin (RXM) administered at the daily dosage of one tablet (150 mg) for 3 months in 30 patients with chronic sinusitis. The effectiveness of this drug was evaluated on a four-point scale. Subjective and objective symptoms disappeared or decreased markedly, especially postnasal drip and nature of discharge in 80 percent or more of the patients. All symptoms significantly decreased (P < 0.001; headache P < 0.05), except for the sensation of foul odor. Symptoms improved even in those cases in which Haemophilus influenzae was detected. It is suggested that RXM produce some clinically beneficial effect through an immunological and or anti-inflammatory mechanisms in addition to its antibiotic effect.
我们研究了罗红霉素（RXM）对30例慢性鼻窦炎患者的临床疗效，这些患者每日服用一片（150毫克）该药，疗程为3个月。该药物的疗效按四分制进行评估。主观和客观症状消失或明显减轻，尤其是80%或更多患者的鼻后滴漏和分泌物性质。除了恶臭感外，所有症状均显著减轻（P<0.001；头痛P<0.05）。即使在检测到流感嗜血杆菌的病例中，症状也有所改善。这表明罗红霉素除了具有抗生素作用外，还通过免疫和/或抗炎机制产生了一些临床有益效果。
