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[继发于甲巯咪唑诱导的粒细胞缺乏症患者的毛霉菌病病例报告]

[Case report of mucormycosis in a patient with secondary methimazole-induced agranulocytosis].

作者信息

Ramírez Claudia, Hernández Alex Francisco, Méndez Verna, Trejo Silvia, Contreras Roxana, Espinosa de los Monteros Ana Laura, Gómez Luz Maria, Mercado Moisés

机构信息

Departamentos de Endocrinologla, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México D.F., México.

出版信息

Gac Med Mex. 2009 May-Jun;145(3):235-8.

Abstract

Agranulocytosis is a rare side effect of antithyroid drugs, it occurs in less than 0.5% of patients, usually during the first few months of treatment. It is considered to be the most serious adverse effect of these medications since it may be complicated by serious, life-threatening infections. Mucormycosis is a severe mycotic infection that usually develops in immunocompromised hosts, such aspatients with diabetes mellitus, hematologic malignancies or immunosuppressive therapy. The association of mucormycosis with methimazole-induced agranulocytosis has not been previously described. The objective of this case presentation is to analyze the case ofa woman with diffuse toxic goiter and methimazole-induced agranulocytosis who developed rhino-palatal mucormycosis.

摘要

粒细胞缺乏症是抗甲状腺药物罕见的副作用,发生率低于0.5%的患者,通常在治疗的最初几个月内出现。它被认为是这些药物最严重的不良反应,因为它可能并发严重的、危及生命的感染。毛霉菌病是一种严重的真菌感染,通常发生在免疫功能低下的宿主中,如糖尿病患者、血液系统恶性肿瘤患者或接受免疫抑制治疗的患者。毛霉菌病与甲巯咪唑引起的粒细胞缺乏症之间的关联此前尚未见报道。本病例报告的目的是分析一例患有弥漫性毒性甲状腺肿并由甲巯咪唑引起粒细胞缺乏症的女性患者,该患者发生了鼻腭部毛霉菌病。

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