Kent Jacqueline C, Arthur Peter G, Mitoulas Leon R, Hartmann Peter E
School of Biomedical, Biomolecular and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, Crawley, WA, Australia.
Breastfeed Rev. 2009 Jul;17(2):5-11.
Adequate calcium intake is vital for infant health, and some cases of rickets have been associated with a low concentration of calcium in breastmilk. The concentration of calcium in breastmilk has been shown to vary widely both between mothers, and over the course of lactation. To address potential concerns about the adequacy of calcium intake for infants who are exclusively breastfed, we discuss the factors likely to be affecting the concentration of calcium in breastmilk. We review and provide new evidence for a physicochemical model of the interactions of calcium with other components of breastmilk, particularly phosphate, citrate and casein. A proposed mechanism for the control of the concentration of calcium in milk is described that highlights the influence of the concentrations of citrate and casein. Understanding these interactions clarifies why the concentration of calcium in breastmilk is not affected by manipulations of maternal dietary calcium and vitamin D.
充足的钙摄入对婴儿健康至关重要，一些佝偻病病例与母乳中钙浓度低有关。母乳中的钙浓度已被证明在母亲之间以及哺乳期过程中差异很大。为了解决对纯母乳喂养婴儿钙摄入充足性的潜在担忧，我们讨论了可能影响母乳中钙浓度的因素。我们回顾并提供了钙与母乳其他成分（特别是磷酸盐、柠檬酸盐和酪蛋白）相互作用的物理化学模型的新证据。描述了一种控制牛奶中钙浓度的拟议机制，该机制突出了柠檬酸盐和酪蛋白浓度的影响。了解这些相互作用有助于解释为什么母乳中钙的浓度不受母亲膳食钙和维生素D摄入量的影响。
