Barlowe Charles
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
Dev Cell. 2009 Aug;17(2):157-8. doi: 10.1016/j.devcel.2009.07.019.
The endoplasmic reticulum (ER) adopts a remarkable array of flattened membrane structures and branched tubular networks to support cellular function. Recent studies reveal that the integral membrane atlastin GTPases, which are linked to neurodegenerative diseases, catalyze membrane fusion and are required for the formation of branched membrane networks characteristic of the ER.
内质网(ER)呈现出一系列显著的扁平膜结构和分支管状网络,以支持细胞功能。最近的研究表明,与神经退行性疾病相关的整合膜atlastin GTP酶催化膜融合,并且是内质网特有的分支膜网络形成所必需的。