Wickström Sara A, Fässler Reinhard
Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
Dev Cell. 2009 Aug;17(2):158-60. doi: 10.1016/j.devcel.2009.07.023.
Cell invasion through the basement membrane, a process important for both development and disease pathogenesis, depends on an interplay of adhesive, force transducing, proteolytic, and chemotactic machineries. The mechanisms whereby these different processes are integrated on the cellular level have remained elusive. In this issue of Developmental Cell, Sherwood and coworkers now identify integrins as integration platforms for a specialized invasive membrane domain in C. elegans.
细胞通过基底膜的侵袭是一个对发育和疾病发病机制都很重要的过程，它依赖于黏附、力传导、蛋白水解和趋化机制之间的相互作用。这些不同过程在细胞水平上整合的机制仍然不清楚。在本期《发育细胞》中，舍伍德及其同事现在确定整合素是秀丽隐杆线虫中一个特殊侵袭膜结构域的整合平台。
