Zeltz Cédric, Brézillon Stéphane, Perreau Corinne, Ramont Laurent, Maquart François-Xavier, Wegrowski Yanusz
Laboratoire de Biochimie Médicale et de Biologie Moléculaire, CNRS UMR 6237, Université Reims-Champagne-Ardenne, F-51095 Reims, France.
FEBS Lett. 2009 Sep 17;583(18):3027-32. doi: 10.1016/j.febslet.2009.08.012. Epub 2009 Aug 15.
We previously showed that lumican decreases melanoma progression. The aim of the present study was to determine the active sequence of the lumican core protein responsible for the inhibition of melanoma cell migration. Using different recombinant and synthetic peptides derived from lumican, we localized an active site in the leucine-rich repeat 9 domain of the lumican core protein. We propose the name lumcorin (fragment of lumican core protein) for the active peptide derived from this site. Lumcorin was able to inhibit melanoma cell migration in vitro.
我们之前的研究表明，核心蛋白聚糖可降低黑色素瘤的进展。本研究的目的是确定核心蛋白聚糖核心蛋白中负责抑制黑色素瘤细胞迁移的活性序列。我们使用了源自核心蛋白聚糖的不同重组肽和合成肽，将核心蛋白聚糖核心蛋白富含亮氨酸重复序列9结构域中的一个活性位点进行了定位。我们为源自该位点的活性肽提议命名为lumcorin（核心蛋白聚糖核心蛋白片段）。Lumcorin能够在体外抑制黑色素瘤细胞的迁移。
