Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense - Darcy Ribeiro, 2000 Parque Califórnia, RJ CEP 28013-602, Brazil.
Peptides. 2009 Dec;30(12):2103-7. doi: 10.1016/j.peptides.2009.08.008. Epub 2009 Aug 15.
Significant effort has been made world-wide to boost biofuels with the expectation of a positive contribution to renewable fuel and greenhouse gas reduction. Jatropha curcas L. has proved to be an opportunistic crop in tropical areas, particularly in unfavorable environments. For this reason, analyses of toxicity and allergy caused by its seeds and pollen are necessary. A 12kDa, allergenic 2S albumin, denoted Jat c 1, was isolated from Physic nut (J. curcas) seeds. Jat c 1 binds IgE attached to rat mast cells, inducing histamine release. It also showed strong cross-reactivity with the major allergens from castor bean, Ric c 1 and Ric c 3.
全世界都在努力推动生物燃料的发展，期望其能为可再生燃料和温室气体减排做出积极贡献。麻疯树已被证明是热带地区一种具有发展潜力的作物，特别是在不利的环境条件下。因此，有必要对其种子和花粉引起的毒性和过敏反应进行分析。从麻疯树种子中分离到一种 12kDa 的过敏蛋白，命名为 Jat c 1。Jat c 1 与附着在大鼠肥大细胞上的 IgE 结合，诱导组胺释放。它还与蓖麻的主要过敏原 Ric c 1 和 Ric c 3 表现出很强的交叉反应性。
