Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156-756, South Korea.
Fitoterapia. 2010 Mar;81(2):85-92. doi: 10.1016/j.fitote.2009.08.008. Epub 2009 Aug 15.
Heme oxygenase-1 (HO-1) is one of the antioxidant enzymes which help protect against cellular damage. The present study examined the ability of Quercetin-3-O-beta-D-glucuronopyranoside (QGC), flavonoid glucoside extracted from Rumex Aquaticus Herba, to induce expression of HO-1 and analyzed its signaling mechanism in cultured feline esophageal epithelial cells (EEC). Culture of the esophageal epithelial cells from cat was prepared. The data suggested that QGC could result in enhanced antioxidant enzyme defense system via HO-1 expression and Nrf2 translocation involving both the ERK and PI3K-Akt pathways as well as partly PKC pathways in EEC.
血红素加氧酶-1（HO-1）是一种抗氧化酶，有助于防止细胞损伤。本研究检测了从酸模草中提取的类黄酮糖苷槲皮素-3-O-β-D-葡萄糖醛酸苷（QGC）诱导猫食道上皮细胞（EEC）中 HO-1 表达的能力，并分析了其信号转导机制。培养猫的食道上皮细胞。数据表明，QGC 可以通过 HO-1 表达和 Nrf2 转位增强抗氧化酶防御系统，涉及 EEC 中的 ERK 和 PI3K-Akt 途径以及部分 PKC 途径。
