从酸橙（芸香科）种子中分离得到的一种新型抗真菌蒽醌类化合物。
A novel antifungal anthraquinone from seeds of Aegle marmelos Correa (family Rutaceae).
机构信息
Department of Chemistry, Banaras Hindu University, Varanasi-221005, India.
出版信息
Fitoterapia. 2010 Mar;81(2):104-7. doi: 10.1016/j.fitote.2009.08.009. Epub 2009 Aug 15.
A new anthraquinone, 1-methyl-2-(3'-methyl-but-2'-enyloxy)-anthraquinone (1) has been isolated from seeds of Aegle marmelos Correa and was characterized on the basis of spectral analysis (UV, IR, 1H NMR, 13C NMR, 2D NMR and mass spectroscopy). The compound exhibited significant antifungal activity against pathogenic strains of Aspergillus species and Candida albicans in disc diffusion assay (MIC value of 6.25 microg/disc), microbroth dilution and percent spore germination inhibition assays (MIC value of 31.25-62.5 microg/ml).
从酸橙种子中分离得到一种新的蒽醌类化合物 1-甲基-2-(3'-甲基-2'-烯丙氧基）蒽醌（1），并通过光谱分析（UV、IR、1H NMR、13C NMR、2D NMR 和质谱）对其进行了表征。该化合物在圆盘扩散试验（MIC 值为 6.25μg/disc）、微量稀释法和孢子发芽抑制百分比试验中对曲霉菌属和白色念珠菌等致病性菌株表现出显著的抗真菌活性（MIC 值为 31.25-62.5μg/ml）。
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