National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, Cincinnati, Ohio 45226, USA.
Neurotoxicol Teratol. 2009 Nov-Dec;31(6):364-71. doi: 10.1016/j.ntt.2009.08.003. Epub 2009 Aug 15.
The relationship between the blood lead concentration and cognitive function in children and adults with different ALAD genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. In adults 20 to 59 years old, mean reaction time decreased as the blood lead concentration increased in the ALAD rs1800435 CC/CG group. This represents an improvement in performance. In adults 60 years and older, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. The serum homocysteine concentration increased as the blood lead concentration increased in adults 20 to 59 years old and 60 years and older, but there were no differences between genotypes. The mean blood lead concentration of children with the ALAD rs1800435 CC/CG genotype was less than that of children with the GG genotype.
研究了参加第三次国家健康和营养检查调查的不同 ALAD 基因型的儿童和成人的血铅浓度与认知功能之间的关系，并探讨了血铅与血清同型半胱氨酸浓度之间的关系。在 12 至 16 岁的儿童中，基因型之间的认知功能与血铅浓度之间没有差异。在 20 至 59 岁的成年人中，ALAD rs1800435 CC/CG 组的平均反应时间随着血铅浓度的升高而降低。这代表着性能的提高。在 60 岁及以上的成年人中，基因型之间的认知功能与血铅浓度之间没有差异。血清同型半胱氨酸浓度随着 20 至 59 岁和 60 岁及以上成年人的血铅浓度的升高而升高，但基因型之间没有差异。ALAD rs1800435 CC/CG 基因型儿童的平均血铅浓度低于 GG 基因型儿童。
