National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA.
Neurotoxicol Teratol. 2010 Mar-Apr;32(2):262-72. doi: 10.1016/j.ntt.2009.12.004. Epub 2009 Dec 18.
The relationship between the blood lead concentration and cognitive function in children and adults with different VDR genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, performance on the digit span and arithmetic tests as a function of the blood lead concentration varied by VDR rs2239185 and VDR rs731236 genotypes. Decreases in performance occurred in some genotypes, but not in others. In adults 20 to 59 years old, performance on the symbol-digit substitution test as a function of the blood lead concentration varied by VDR rs2239185-rs731236 haplotype. In the 12 to 16 year old children and adults 60 or more years old, the relationship between the serum homocysteine and blood lead concentrations varied by VDR genotype. The mean blood lead concentrations of the children and adults did not vary by VDR genotype.
研究了参加第三次国家健康和营养检查调查的不同 VDR 基因型的儿童和成人的血铅浓度与认知功能之间的关系，并研究了血铅与血清同型半胱氨酸浓度之间的关系。在 12 至 16 岁的儿童中，血铅浓度与数字跨度和算术测试的表现因 VDR rs2239185 和 VDR rs731236 基因型而异。在某些基因型中会出现表现下降的情况，但在其他基因型中则不会。在 20 至 59 岁的成年人中，血铅浓度与符号数字替代测试的表现因 VDR rs2239185-rs731236 单倍型而异。在 12 至 16 岁的儿童和 60 岁或以上的成年人中，血清同型半胱氨酸与血铅浓度之间的关系因 VDR 基因型而异。儿童和成年人的平均血铅浓度不因 VDR 基因型而异。
