Matsuo Yayoi, Kamezaki Kenjiro, Takeishi Shoichiro, Takenaka Katsuto, Eto Tetsuya, Nonami Atsushi, Miyamoto Toshihiro, Iwasaki Hiromi, Harada Naoki, Nagafuji Koji, Teshima Takanori, Akashi Koichi
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka.
Intern Med. 2009;48(16):1453-6. doi: 10.2169/internalmedicine.48.2003. Epub 2009 Aug 17.
We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplantation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting of a therapeutic dose of cyclosporine A and a maintenance dose of methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare and remains controversial, presentation of neurological symptoms after allogeneic BMT warrants consideration of GVHD in the differential diagnosis.
我们描述了一例在异基因骨髓移植（BMT）治疗骨髓增生异常综合征后发生的、类似多发性硬化症的脑脊髓炎病例，该病例与慢性移植物抗宿主病（GVHD）相关。由治疗剂量的环孢素A和维持剂量的甲泼尼龙组成的免疫抑制疗法对治疗症状有效。尽管中枢神经系统GVHD非常罕见且仍存在争议，但异基因BMT后出现神经症状在鉴别诊断时仍需考虑GVHD。
