给予促肾上腺皮质激素（ACTH）和地塞米松后雄性白尾鹿的血浆促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮、催乳素和雄烯二酮水平。

Plasma LH, FSH, testosterone, prolactin and androstenedione in male white-tailed deer after ACTH and dexamethasone administration.

Bubenik G A, Smith J H, Pomerantz D K, Schams D

Department of Zoology, University of Guelph, Ontario, Canada.

Comp Biochem Physiol A Comp Physiol. 1990;95(1):163-9. doi: 10.1016/0300-9629(90)90026-o.

Abstract

In order to investigate the role of the adrenocortical system in the regulation of plasma levels of reproductive hormones, adult male white-tailed deer (five intact and one castrated) from a captive herd were sedated with xylazine and ketamine and then challenged with various doses of ACTH with and without dexamethasone (DX) pretreatment. 2. Plasma levels of LH, testosterone (T), FSH, prolactin (PRL) and androstenedione (A) were determined by RIA in serial samples taken from the jugular vein. 3. An increase of A levels detected after ACTH in both intact and castrated deer indicated stimulation of secretion of adrenal androgens by ACTH. 4. No effect on FSH and PRL levels was observed in either group. 5. A significant decline of LH and T observed in various treatments could not be attributed to ACTH or DX administration. It is speculated that the decrease may be caused by anaesthetics which alleviate the stress induced in deer by the pre-immobilization activities.

摘要

为了研究肾上腺皮质系统在调节生殖激素血浆水平中的作用，对圈养鹿群中的成年雄性白尾鹿（5只未阉割和1只阉割）用赛拉嗪和氯胺酮进行镇静，然后在有和没有地塞米松（DX）预处理的情况下，用不同剂量的促肾上腺皮质激素（ACTH）进行刺激。2. 通过放射免疫分析法（RIA）测定从颈静脉采集的系列样本中促黄体生成素（LH）、睾酮（T）、促卵泡激素（FSH）、催乳素（PRL）和雄烯二酮（A）的血浆水平。3. 在未阉割和阉割鹿中，ACTH刺激后检测到A水平升高，表明ACTH刺激了肾上腺雄激素的分泌。4. 两组中均未观察到对FSH和PRL水平有影响。5. 在各种处理中观察到的LH和T的显著下降不能归因于ACTH或DX的给药。据推测，这种下降可能是由麻醉剂引起的，麻醉剂减轻了鹿在固定前活动中所诱导的应激。