Angulo J A, Cadet J L, McEwen B S
Columbia University, College of Physicians and Surgeons, Department of Neurology, New York, NY.
Eur J Pharmacol. 1990 Jan 10;175(2):225-8. doi: 10.1016/0014-2999(90)90236-y.
We determined proenkephalin and protachykinin mRNA levels in the striatum of the rat by in situ hybridization histochemistry in controls and in animals treated for 14 days with the potential neuroleptic drug BMY 14802 (15 mg/kg i.p.). Proenkephalin mRNA levels were increased relative to control values by 107, 88 and 94% and protachykinin mRNA levels decreased by 17, 28 and 10% in the rostral, medial and caudal aspects of the caudate-putamen, respectively. The data suggest that sigma receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons.
我们通过原位杂交组织化学法，测定了对照组大鼠以及用潜在抗精神病药物BMY 14802（腹腔注射15 mg/kg）处理14天的大鼠纹状体中脑啡肽原和速激肽原mRNA水平。在尾状核-壳核的前部、中部和后部，脑啡肽原mRNA水平相对于对照值分别增加了107%、88%和94%，而速激肽原mRNA水平分别降低了17%、28%和10%。这些数据表明，σ受体活性直接或间接影响纹状体神经元中脑啡肽原和速激肽原mRNA的表达。
