Division of Gastroenterology, University of Florida Health Science Center/Jacksonville, Suite 300, Jacksonville, FL 32207, USA.
Dig Dis Sci. 2010 Jun;55(6):1622-6. doi: 10.1007/s10620-009-0918-x. Epub 2009 Aug 18.
The incidence of esophageal adenocarcinoma has increased over the last 30 years, especially in non-Hispanic whites (nHw). Recent work indicates an increase in Hispanic Americans (HA). It is important to understand the effect of ethnicity on cancer occurrence over a prolonged interval.
We searched the New Mexico Tumor Registry for all cases of esophageal cancer from 1 January 1973 to 31 December 2002. Inclusion criteria were histologic diagnosis of adenocarcinoma or squamous cell carcinoma, ethnicity and gender. Incidence rates for both were compared among ethnic groups in 5-year intervals.
Nine hundred eighty-eight patients met the criteria. Esophageal adenocarcinoma incidence rates/100,000 population increased significantly over 30 years; 1973-1977, 0.4 cases; 1978-1982, 0.4 cases; 1983-1987, 0.6 cases; 1988-1992, 1.2 cases, 1993-1997, 1.6 cases and 1998-2002, 2.2 cases; P < 0.001. Squamous cell carcinoma incidence rates remained unchanged during the interval. In nHw and HA, adenocarcinoma incidence rates increased significantly during the study period. In all minority groups, squamous cell carcinoma remained the major type.
Esophageal adenocarcinoma incidence among nHw and HA increased from 1973 to 2002 in New Mexico. Squamous cell carcinoma remains predominant in minorities. Ethnicity may influence the histology or indicate an increased risk for certain types of esophageal cancer.
过去 30 年来，食管腺癌的发病率一直在上升，尤其是在非西班牙裔白人（nHw）中。最近的研究表明，西班牙裔美国人（HA）的发病率也在上升。了解不同种族在较长时间内对癌症发生的影响很重要。
我们在新墨西哥肿瘤登记处检索了 1973 年 1 月 1 日至 2002 年 12 月 31 日期间所有食管癌症病例。纳入标准为组织学诊断为腺癌或鳞状细胞癌、种族和性别。我们比较了不同种族在 5 年间隔内的发病率。
988 例患者符合标准。食管腺癌发病率/10 万人口在 30 年内显著增加；1973-1977 年为 0.4 例，1978-1982 年为 0.4 例，1983-1987 年为 0.6 例，1988-1992 年为 1.2 例，1993-1997 年为 1.6 例，1998-2002 年为 2.2 例；P < 0.001。在此期间，鳞状细胞癌的发病率保持不变。在 nHw 和 HA 中，腺癌发病率在研究期间显著增加。在所有少数民族中，鳞状细胞癌仍然是主要类型。
在新墨西哥州，nHw 和 HA 中的食管腺癌发病率从 1973 年到 2002 年有所增加。在少数民族中，鳞状细胞癌仍然占主导地位。种族可能影响组织学或表明某些类型的食管癌风险增加。
