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桥粒芯糖蛋白 3 在鼻腔鼻窦内翻性乳头状瘤和鳞状细胞癌中过表达。

Desmoglein 3 is overexpressed in inverted papilloma and squamous cell carcinoma of sinonasal cavity.

机构信息

Department of Otolaryngoloy-Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan.

出版信息

Laryngoscope. 2010 Jan;120(1):26-9. doi: 10.1002/lary.20151.

Abstract

OBJECTIVES/HYPOTHESIS: We sought to investigate the role of desmoglein 3 in pathogenesis of sinonasal inverted papilloma (IP) and its malignant transformation.

METHODS

Fifteen subjects with sinonasal IP and 15 subjects of normal sphenoid sinus mucosa were enrolled. Each specimen was divided into two portions: one for mRNA expression analysis by real-time polymerase chain reaction, and the other for detection of targeted proteins by immunohistochemistry analysis. In addition, another 10 cases of IP with squamous cell carcinoma (SCC) were added for immunohistochemistry analysis.

RESULTS

The mRNA expression level of desmoglein 3 was significantly higher in IP tissues than in the normal sinus mucosa (P < .001). In immunohistochemistry study, desmoglein 3 was detected in plasma membrane areas of IP and IP with SCC tissues, but no obvious expression was found in normal sinus mucosa (total score; both P < .001). Positive desmoglein 3 staining was strongly present in nearly all malignant transformation areas of IP with SCC cases (90%), but only in scattered areas of some cases of IP (53%) (total score; P < .001).

CONCLUSIONS

Desmoglein 3 was overexpressed in IP and IP with SCC, and the overexpression was correlated with malignant transformation of IP. It may provide valuable insight into the pathobiology of this disease, and can potentially provide a venue to predict malignant transformation in sinonasal IP.

摘要

目的/假设:我们旨在研究桥粒芯糖蛋白 3 在鼻内翻性乳头状瘤(IP)发病机制及其恶性转化中的作用。

方法

纳入 15 例鼻 IP 患者和 15 例正常蝶窦黏膜患者。每个标本分为两部分:一部分用于实时聚合酶链反应的 mRNA 表达分析,另一部分用于免疫组织化学分析检测靶向蛋白。此外,又增加了 10 例伴有鳞状细胞癌(SCC)的 IP 病例用于免疫组织化学分析。

结果

IP 组织中桥粒芯糖蛋白 3 的 mRNA 表达水平明显高于正常鼻窦黏膜(P<0.001)。在免疫组织化学研究中,桥粒芯糖蛋白 3 在 IP 和伴有 SCC 的 IP 组织的质膜区域中被检测到,但在正常鼻窦黏膜中未发现明显表达(总评分;均 P<0.001)。伴有 SCC 的 IP 中几乎所有恶性转化区域的阳性桥粒芯糖蛋白 3 染色均强烈存在(90%),但在某些 IP 病例的散在区域中仅存在(53%)(总评分;P<0.001)。

结论

桥粒芯糖蛋白 3 在 IP 和伴有 SCC 的 IP 中过度表达,且过度表达与 IP 的恶性转化相关。这可能为该疾病的病理生物学提供有价值的见解,并可能为预测鼻内翻性乳头状瘤的恶性转化提供一个场所。

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