Department of Pathology, Faculty of Medicine, Ain Shams University, Egypt.
Anal Cell Pathol (Amst). 2021 Feb 16;2021:6639834. doi: 10.1155/2021/6639834. eCollection 2021.
Sinonasal inverted papilloma (IP) has a propensity for malignant transformation. Although the IP-associated squamous cell carcinoma (SCC) is rare, it has a poor prognosis. To the best of our knowledge, this is the first study to assess IMP3 immunohistochemical (IHC) expression in sinonasal tumors and to compare it to the Ki-67 IHC expression and to other established clinicopathological parameters. A retrospective study was conducted on three groups which consisted of 72 cases of sinonasal IP, 20 age-matched samples of normal respiratory epithelium, and 15 cases of sinonasal SCC associated with IP, which were obtained from the archives of the Pathology Lab of Ain Shams University Specialized and Ain Shams University Hospitals during the period from January 2012 to December 2019. An IHC study was performed to evaluate IMP3 and Ki-67 expression in the three groups, with correlation of IMP3 expression to established clinicopathological parameters of sinonasal SCC on top of IP. Both IMP3 and Ki-67 showed a sharp rise in expression in the sinonasal SCC group. In addition, there were statistically significant differences in expression values between the 3 groups ( = 0.001). Receiver Operating Characteristic (ROC) analysis revealed that IMP3 and Ki-67 could be used to discriminate sinonasal SCC from control and IP lesions, with sensitivity and specificity of 100% and 81.5% for IMP3, respectively, and 100% and 62.5% for Ki-67, respectively. Spearman's rho revealed that both IMP3 and Ki-67 were significantly related to the lymph node and tumor stages but not to the tumor grade. ROC analysis was performed to select cut-off scores for progression and survival for IMP3, and accordingly, Kaplan-Meier analysis showed correlation between IMP3 and overall survival, local recurrence-free survival, and metastasis-free survival in sinonasal SCC cases at the selected cut-off values. Based on our results, IMP3 could serve as a promising diagnostic, prognostic, and therapeutic marker for IP-associated sinonasal SCC.
鼻窦内翻性乳头状瘤（IP）有恶性转化的倾向。虽然 IP 相关的鳞状细胞癌（SCC）很少见，但预后较差。据我们所知，这是第一项评估 IMP3 免疫组织化学（IHC）表达在鼻窦肿瘤中的研究，并将其与 Ki-67 IHC 表达和其他已建立的临床病理参数进行比较。一项回顾性研究对三组进行了研究，共包括 72 例鼻窦 IP、20 例年龄匹配的正常呼吸上皮样本和 15 例与 IP 相关的鼻窦 SCC 病例，这些病例来自 Ain Shams 大学专门病理实验室和 Ain Shams 大学医院的档案，时间为 2012 年 1 月至 2019 年 12 月。进行了 IHC 研究以评估三组中的 IMP3 和 Ki-67 表达，并将 IMP3 表达与 IP 上的鼻窦 SCC 的既定临床病理参数相关联。IMP3 和 Ki-67 在鼻窦 SCC 组中的表达均急剧上升。此外，三组之间的表达值存在统计学差异（= 0.001）。接收者操作特征（ROC）分析表明，IMP3 和 Ki-67 可用于区分鼻窦 SCC 与对照和 IP 病变，IMP3 的敏感性和特异性分别为 100%和 81.5%，Ki-67 的敏感性和特异性分别为 100%和 62.5%。Spearman's rho 表明，IMP3 和 Ki-67 均与淋巴结和肿瘤分期显著相关，但与肿瘤分级无关。进行 ROC 分析以选择用于进展和生存的 IMP3 截止评分，并且 Kaplan-Meier 分析显示在选定的截止值下，IMP3 与鼻窦 SCC 病例的总生存、局部无复发生存和无转移生存相关。根据我们的结果，IMP3 可以作为 IP 相关的鼻窦 SCC 的有前途的诊断、预后和治疗标志物。
