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蛇毒磷脂酶A2的结构与药理特性

Structural and pharmacological features of phospholipases A2 from snake venoms.

作者信息

de Paula Rafael Cisne, Castro Helena Carla, Rodrigues Carlos Rangel, Melo Paulo Assis, Fuly André Lopes

机构信息

Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brasil.

出版信息

Protein Pept Lett. 2009;16(8):899-907. doi: 10.2174/092986609788923365.

DOI:10.2174/092986609788923365
PMID:19689416
Abstract

Phospholipases A(2) enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA(2)s including biological and structural features, interaction with binding receptors, inhibitors used on structure-function relationship studies and highlighting the mechanism of action and role of the snake venom PLA(2)s products, the lysophosphatidylcholine.

摘要

磷脂酶A(2) 酶存在于许多生物来源中，包括蛇毒。在此，我们综述了磷脂酶A(2) 的多个方面，包括生物学和结构特征、与结合受体的相互作用、用于结构-功能关系研究的抑制剂，并着重介绍了蛇毒磷脂酶A(2) 的产物溶血磷脂酰胆碱的作用机制和作用。

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