Patterson Julie V, Sandman Curt A, Ring Alex, Jin Yi, Bunney William E
Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, California 92868, USA.
Bipolar Disord. 2009 Sep;11(6):596-609. doi: 10.1111/j.1399-5618.2009.00734.x.
Progress toward understanding the neurobiological and genetic underpinnings of bipolar disorder has been limited by the scarcity of potential biological markers that predict its occurrence. A measure of the integrity of brain inhibitory function, sensory gating, measured using the amplitude of the evoked potential at 50 ms to the first of two paired clicks divided by the response to the second, has been characterized as a biological marker for schizophrenia. Currently, no such biological marker exists for bipolar disorder. The goal of this research was to determine how gating of an auditory brain potential at 85 ms (P85), not previously examined in sensory gating studies, differentiated control and patient groups.
P50 and P85 auditory evoked potentials were collected from individuals diagnosed with schizoaffective disorder (n = 45), paranoid schizophrenia (n = 66), and bipolar I disorder (n = 42) using DSM-IV criteria and the Structured Clinical Interview for DSM-IV; and from 56 healthy controls.
The P85 gating ratio was significantly larger in the bipolar disorder group compared to each of the other groups (F(3,204) = 5.47, p = 0.001, and post-hoc tests). The P50 gating ratio was significantly larger for the schizoaffective group than for the control group (F(3,204) = 2.81, p = 0.040), but did not differ from the ratio for the schizophrenia, paranoid type (p = 0.08) and bipolar groups.
The previously unstudied P85 gating ratio may provide a new marker specific to bipolar disorder. The findings will promote further studies to investigate the unique contribution of this measure as an endophenotype.
由于预测双相情感障碍发生的潜在生物标志物稀缺，对该疾病神经生物学和遗传学基础的理解进展有限。一种用于测量大脑抑制功能完整性的方法，即感觉门控，通过测量对两个配对点击中第一个点击后50毫秒诱发电位的振幅除以对第二个点击的反应来衡量，已被确定为精神分裂症的生物标志物。目前，双相情感障碍尚无此类生物标志物。本研究的目的是确定85毫秒听觉脑电位（P85）的门控情况（此前感觉门控研究中未涉及）如何区分对照组和患者组。
使用《精神疾病诊断与统计手册》第四版（DSM-IV）标准和DSM-IV结构化临床访谈，从45名被诊断为分裂情感性障碍、66名偏执型精神分裂症患者、42名双相I型障碍患者以及56名健康对照者中收集P50和P85听觉诱发电位。
与其他各组相比，双相情感障碍组的P85门控率显著更高（F(3,204) = 5.47，p = 0.001，事后检验）。分裂情感性障碍组的P50门控率显著高于对照组（F(3,204) = 2.81，p = 0.040），但与偏执型精神分裂症组和双相情感障碍组的该比率无差异（p = 0.08）。
此前未被研究的P85门控率可能为双相情感障碍提供一种新的特异性标志物。这些发现将推动进一步研究，以探究该测量指标作为内表型的独特作用。
