P50感觉门控缺陷是双相情感障碍和精神分裂症易感性的常见标志。
P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia.
作者信息
Sánchez-Morla E M, García-Jiménez M A, Barabash A, Martínez-Vizcaíno V, Mena J, Cabranes-Díaz J A, Baca-Baldomero E, Santos J L
机构信息
Department of Psychiatry, Hospital General Universitario de Guadalajara, Guadalajara, Spain.
出版信息
Acta Psychiatr Scand. 2008 Apr;117(4):313-8. doi: 10.1111/j.1600-0447.2007.01141.x. Epub 2008 Jan 30.
OBJECTIVE
P50 gating in schizophrenia has contributed much to our understanding of the pathophysiology of the illness. We examined euthymic bipolar patients to determine if they also have a P50 gating deficit.
METHOD
P50 gating was measured in 81 euthymic bipolar patients (50 with a lifetime history of psychotic symptoms), 92 stable schizophrenic patients, and 67 control subjects.
RESULTS
P50 gating was significantly lower in control subjects than in bipolar patients with a lifetime history of psychosis (P = 0.001) and schizophrenic patients (P = 0.0001). In all patient groups, the percentage of patients with P50 gating was higher than in the control group (chi(2) = 30.596; P < 0.0001). There was no statistically significant correlation between P50 gating and other clinical variables.
CONCLUSION
Our data suggest that P50 gating deficit is a neurobiological marker that is present in stable schizophrenic patients and euthymic bipolar patients.
目的
精神分裂症中的P50门控现象对我们理解该疾病的病理生理学有很大帮助。我们对心境正常的双相情感障碍患者进行了检查，以确定他们是否也存在P50门控缺陷。
方法
对81名心境正常的双相情感障碍患者（其中50名有终生精神病性症状史）、92名病情稳定的精神分裂症患者和67名对照者进行了P50门控测量。
结果
对照者的P50门控显著低于有终生精神病性症状史的双相情感障碍患者（P = 0.001）和精神分裂症患者（P = 0.0001）。在所有患者组中，存在P50门控缺陷的患者百分比高于对照组（χ² = 30.596；P < 0.0001）。P50门控与其他临床变量之间无统计学显著相关性。
结论
我们的数据表明，P50门控缺陷是一种神经生物学标志物，存在于病情稳定的精神分裂症患者和心境正常的双相情感障碍患者中。
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