Antonaci S, Garofalo A R, Chicco C, Polignano A V, Pugliese P, Misefari A, Jirillo E
Fisiopatologia Medica I, University of Bari Medical School, Italy.
J Clin Lab Anal. 1990;4(1):16-21. doi: 10.1002/jcla.1860040106.
Since previous data have provided conflicting results on immunoresponsiveness in senile dementia, Alzheimer type (SDAT), we evaluated the immune function in groups of SDAT patients and aged and young donors. In comparison to the younger subjects, SDAT and aged subjects did not exhibit significant differences in lymphocyte surface markers. Both groups of aged donors showed decreased B cell polyclonal responsiveness in a nonspecific T cell-driven B lymphocyte differentiation system. The use of an antigen-specific induction assay revealed an imbalance of T helper (Th) or T suppressor function in the elderly, while SDAT individuals were characterized by decreased Th activity. At the same time, aged individuals manifested an impairment of leukocyte-inhibiting factor (LIF) and lymphocyte-derived chemotactic factor production; a selective deficit of LIF release was seen in SDAT. Finally, elderly individuals displayed a decline of polymorphonuclear cell (PMN)-mediated functions and monocyte phagocytosis; only a decrease in PMN response was observed in SDAT. These results reveal discrepancies in impaired immune responses between SDAT and aging.
由于先前的数据在阿尔茨海默型老年痴呆症（SDAT）的免疫反应性方面给出了相互矛盾的结果，我们对SDAT患者组以及老年和年轻供体的免疫功能进行了评估。与年轻受试者相比，SDAT患者和老年受试者在淋巴细胞表面标志物方面没有显著差异。两组老年供体在非特异性T细胞驱动的B淋巴细胞分化系统中均表现出B细胞多克隆反应性降低。使用抗原特异性诱导试验发现老年人T辅助（Th）或T抑制功能失衡，而SDAT个体的特征是Th活性降低。同时，老年人表现出白细胞抑制因子（LIF）和淋巴细胞衍生趋化因子产生受损；在SDAT中观察到LIF释放存在选择性缺陷。最后，老年人显示多形核细胞（PMN）介导的功能和单核细胞吞噬作用下降；在SDAT中仅观察到PMN反应降低。这些结果揭示了SDAT和衰老在免疫反应受损方面的差异。
