Koren P, Diver-Haber A, Adunsky A, Rabinowitz M, Hershkowitz M
Department of Geriatric Rehabilitation, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
J Gerontol. 1993 May;48(3):B93-6. doi: 10.1093/geronj/48.3.b93.
[3H]-serotonin uptake in platelets was studied in 26 patients with senile dementia of the Alzheimer type (SDAT), 29 age-matched normal elderly persons, and 21 young subjects. The results showed a significantly lower uptake of serotonin into platelets of SDAT patients than in those of elderly controls (p < .02). Uptake of serotonin into platelets of elderly normal subjects was significantly lower than in the young (p < .01). These differences were due to reduced Vmax, whereas Km was unchanged. Isolated plasma from SDAT patients did not affect the uptake of serotonin into platelets of elderly controls, and vice versa, i.e., plasma obtained from elderly controls did not affect serotonin uptake in SDAT patients. The results indicate that serotonin uptake into platelets is reduced in normal aging, and more so in SDAT. Moreover, the reduced uptake in SDAT is not caused by a plasma factor in SDAT patients. No correlation was found between serotonin uptake and degree of cognitive impairment in SDAT patients.
对26例阿尔茨海默型老年痴呆症（SDAT）患者、29例年龄匹配的正常老年人以及21例年轻受试者的血小板中[3H] - 5 - 羟色胺摄取情况进行了研究。结果显示，SDAT患者血小板对5 - 羟色胺的摄取显著低于老年对照组（p < 0.02）。老年正常受试者血小板对5 - 羟色胺的摄取显著低于年轻人（p < 0.01）。这些差异是由于最大摄取速率（Vmax）降低，而米氏常数（Km）不变。SDAT患者的分离血浆不影响老年对照组血小板对5 - 羟色胺的摄取，反之亦然，即从老年对照组获得的血浆不影响SDAT患者血小板对5 - 羟色胺的摄取。结果表明，正常衰老过程中血小板对5 - 羟色胺的摄取会降低，在SDAT患者中降低得更明显。此外，SDAT患者血小板摄取降低并非由SDAT患者血浆中的某种因子所致。在SDAT患者中，未发现5 - 羟色胺摄取与认知障碍程度之间存在相关性。
