Gow A G, Gow D J, Bell R, Simpson J W, Chandler M L, Evans H, Berry J L, Herrtage M E, Mellanby R J
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian, UK.
J Small Anim Pract. 2009 Aug;50(8):426-30. doi: 10.1111/j.1748-5827.2009.00757.x.
Hypoadrenocorticism is a well-described endocrinopathy in dogs that results from deficient production and secretion of glucocorticoids and/or mineralocorticoids. Although hyperkalaemia, hyponatraemia and hypochloraemia are the most common electrolyte disturbances, hypercalcaemia also occurs in approximately 30 per cent of cases. The pathogenesis of hypercalcaemia in dogs with hypoadrenocorticism is unknown. This case series reports ionised calcium, parathyroid hormone, parathyroid hormone-related protein and vitamin D metabolite concentrations that were measured in eight dogs with concurrent hypercalcaemia and hypoadrenocorticism. Ionised calcium was increased in five of seven dogs with hypercalcaemia associated with hypoadrenocorticism. Parathyroid hormone, parathyroid hormone-related protein and 1,25 dihydroxyvitamin D concentrations were within their reference ranges in seven of eight dogs, six of seven cases and six of seven dogs, respectively. This case series highlights that hypercalcaemia associated with hypoadrenocorticism is rarely associated with increases in plasma parathyroid hormone, parathyroid hormone-related protein or serum 1,25 dihydroxyvitamin D concentrations.
肾上腺皮质功能减退症是一种在犬类中被充分描述的内分泌病，由糖皮质激素和/或盐皮质激素分泌不足引起。虽然高钾血症、低钠血症和低氯血症是最常见的电解质紊乱，但高钙血症在约30%的病例中也会出现。肾上腺皮质功能减退症犬发生高钙血症的发病机制尚不清楚。本病例系列报告了8只同时患有高钙血症和肾上腺皮质功能减退症的犬所测量的离子钙、甲状旁腺激素、甲状旁腺激素相关蛋白和维生素D代谢物浓度。在7只与肾上腺皮质功能减退症相关的高钙血症犬中，有5只离子钙升高。甲状旁腺激素、甲状旁腺激素相关蛋白和1,25-二羟维生素D浓度分别在8只犬中的7只、7例中的6例和7只犬中的6例的参考范围内。本病例系列强调，与肾上腺皮质功能减退症相关的高钙血症很少与血浆甲状旁腺激素、甲状旁腺激素相关蛋白或血清1,25-二羟维生素D浓度升高有关。
