Gow A G, Else R, Evans H, Berry J L, Herrtage M E, Mellanby R J
Royal School of Veterinary Studies, Division of Veterinary Clinical Studies, Hospital for Small Animals, Easter Bush Veterinary Centre, The University of Edinburgh, Roslin, Midlothian, UK.
J Small Anim Pract. 2011 Aug;52(8):411-8. doi: 10.1111/j.1748-5827.2011.01082.x.
To compare serum vitamin D metabolites and plasma parathyroid hormone concentrations in dogs with inflammatory bowel disease and normal albumin concentration, dogs with inflammatory bowel disease and hypoalbuminaemia, healthy dogs and hospitalised ill dogs with non-gastrointestinal illness.
Serum 25 hydroxyvitamin D and 1,25 dihydroxyvitamin D concentrations were measured in 36 healthy dogs, 49 hospitalised ill dogs with non-gastrointestinal illnesses, 21 dogs with inflammatory bowel disease and normoalbuminaemia and 12 dogs with inflammatory bowel disease and hypoalbuminaemia. Plasma parathyroid hormone and ionised calcium concentrations were measured in a subset of these dogs.
Concentrations of serum 25 hydroxyvitamin D were lower in hypoalbuminaemic dogs with inflammatory bowel disease than in the healthy dogs (P<0·001), hospitalised ill dogs (P<0·001) and normoalbuminaemic dogs with inflammatory bowel disease (P<0·001). Dogs with inflammatory bowel disease and hypoalbuminaemia had a higher plasma concentration of parathyroid hormone (P<0·01) and lower plasma concentration of ionised calcium (P<0·001) than hospitalised ill dogs. Dogs with inflammatory bowel disease had a positive correlation between serum 25 hydroxyvitamin D concentrations and serum albumin (P<0·0001), serum calcium (P<0·0001) and plasma ionised calcium (P<0·0005) concentrations.
Dogs with inflammatory bowel disease and hypoalbuminaemia frequently have ionised hypocalcaemia, high parathyroid hormone and low serum 25 hydroxyvitamin D concentrations. Further studies are indicated to establish the pathogenesis of this disease complication as well as therapeutic strategies to reverse this state.
比较白蛋白浓度正常的炎症性肠病犬、低白蛋白血症的炎症性肠病犬、健康犬以及患有非胃肠道疾病的住院病犬的血清维生素D代谢物和血浆甲状旁腺激素浓度。
测定了36只健康犬、49只患有非胃肠道疾病的住院病犬、21只白蛋白浓度正常的炎症性肠病犬和12只低白蛋白血症的炎症性肠病犬的血清25羟维生素D和1,25二羟维生素D浓度。对其中一部分犬测定了血浆甲状旁腺激素和离子钙浓度。
低白蛋白血症的炎症性肠病犬的血清25羟维生素D浓度低于健康犬（P<0.001）、住院病犬（P<0.001）和白蛋白浓度正常的炎症性肠病犬（P<0.001）。与住院病犬相比，患有炎症性肠病和低白蛋白血症的犬血浆甲状旁腺激素浓度更高（P<0.01），血浆离子钙浓度更低（P<0.001）。炎症性肠病犬的血清25羟维生素D浓度与血清白蛋白（P<0.0001）、血清钙（P<0.0001）和血浆离子钙（P<0.0005）浓度呈正相关。
患有炎症性肠病和低白蛋白血症的犬经常出现离子钙降低、甲状旁腺激素升高和血清25羟维生素D浓度降低的情况。需要进一步研究以确定这种疾病并发症的发病机制以及逆转这种状态的治疗策略。
