Walmsley G L, Chandler K, Davies E S, Lamb C R, Smyth B, Summers B A
Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, UK.
J Small Anim Pract. 2009 Aug;50(8):435-9. doi: 10.1111/j.1748-5827.2009.00761.x.
A nine-month-old puppy was presented for investigation of seizures. Neurological deficits were found localising to the prosencephalon, mesencephalon and myelencephalon. Magnetic resonance imaging identified multiple, large lesions involving both cerebral hemispheres. Management with antiepileptic and immunomodulatory drugs was instituted; however, the seizures became progressively refractory and the puppy was euthanased. Histopathology following post-mortem examination found a mixed glial cell tumour with discrete areas where neoplastic cells appeared oligodendroglial or astrocytic. Primary intracranial neoplasia is a rare cause of neurological disease in young dogs. Moreover, this case is unusual in terms of both the mixed glial nature of the neoplasm and also its multi-focal distribution.
一只九个月大的幼犬因癫痫发作前来检查。发现神经功能缺损定位于前脑、中脑和延髓。磁共振成像显示双侧大脑半球有多个大的病变。开始使用抗癫痫和免疫调节药物进行治疗；然而，癫痫发作逐渐变得难以控制，最终对该幼犬实施了安乐死。死后组织病理学检查发现是一种混合性神经胶质瘤，在不同区域肿瘤细胞呈现少突胶质细胞或星形胶质细胞的特征。原发性颅内肿瘤是幼犬神经系统疾病的罕见病因。此外，该病例在肿瘤的混合性神经胶质性质及其多灶性分布方面都很不寻常。
