Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843-4467, USA.
Vet Pathol. 2011 Jan;48(1):266-75. doi: 10.1177/0300985810389543. Epub 2010 Nov 8.
Tumors of astrocytic lineage are among the most common primary brain neoplasms in people and dogs. Current understanding of the pathogenesis of astrocytic tumors is limited in dogs compared with humans. In dogs, critical biological data concerning the natural history of disease progression, tumor imaging features, and response to therapeutic intervention are lacking. This review outlines the clinical, genetic, immunologic, and histopathologic characteristics of astrocytic tumors in dogs with special focus on comparative neuro-oncology. Common problems associated with the diagnosis of these neoplasms are summarized. Traditional veterinary histologic typing and grading of astrocytic tumors must be updated and supplemented with molecular data so that future studies directed toward therapeutic intervention and outcome can be optimized.
星形细胞来源的肿瘤是人及犬中最常见的原发性脑肿瘤之一。与人类相比，目前对犬星形细胞瘤发病机制的了解有限。在犬中，关于疾病进展的自然病史、肿瘤影像学特征和对治疗干预的反应的关键生物学数据是缺乏的。本文概述了犬星形细胞瘤的临床、遗传、免疫和组织病理学特征，特别关注比较神经肿瘤学。总结了与这些肿瘤诊断相关的常见问题。传统的兽医组织学类型和星形细胞瘤分级必须更新，并补充分子数据，以便优化针对治疗干预和预后的未来研究。
