NKG2D配体调控的综合观点。
An integrated view of the regulation of NKG2D ligands.
作者信息
Stern-Ginossar Noam, Mandelboim Ofer
机构信息
Lautenberg Center for General and Tumor Immunology, The Hebrew University, The BioMedical Research Institute, Hadassah Medical School, Jerusalem, Israel.
出版信息
Immunology. 2009 Sep;128(1):1-6. doi: 10.1111/j.1365-2567.2009.03147.x.
Abstract
NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T-cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the emphasis on post-transcriptional and post-translational regulation.
摘要
NKG2D是特征最为明确的激活受体之一，表达于自然杀伤细胞和多种T细胞亚群上。该受体识别由细胞应激诱导产生的几种不同配体。在本综述中，我们描述了控制NKG2D配体表达的机制，重点是转录后和翻译后调控。
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