Webcoli：一个用于基于计算机的大规模 E.coli 模型设计和分析的交互式和异步网络应用程序。

WEbcoli: an interactive and asynchronous web application for in silico design and analysis of genome-scale E.coli model.

机构信息

Department of Information Industrial Engineering, CBITRC, Chungbuk National University, Cheongju Chungbuk 361-763, Korea.

出版信息

Bioinformatics. 2009 Nov 1;25(21):2850-2. doi: 10.1093/bioinformatics/btp496. Epub 2009 Aug 17.

DOI:10.1093/bioinformatics/btp496

PMID:19689960

Abstract

SUMMARY

WEbcoli is a WEb application for in silico designing, analyzing and engineering Escherichia coli metabolism. It is devised and implemented using advanced web technologies, thereby leading to enhanced usability and dynamic web accessibility. As a main feature, the WEbcoli system provides a user-friendly rich web interface, allowing users to virtually design and synthesize mutant strains derived from the genome-scale wild-type E.coli model and to customize pathways of interest through a graph editor. In addition, constraints-based flux analysis can be conducted for quantifying metabolic fluxes and charactering the physiological and metabolic states under various genetic and/or environmental conditions.

AVAILABILITY

WEbcoli is freely accessible at http://webcoli.org.

CONTACT

cheld@nus.edu.sg.

摘要

WEbcoli 是一个用于大肠杆菌代谢的计算机辅助设计、分析和工程的网络应用程序。它是利用先进的网络技术设计和实现的，从而提高了可用性和动态网络访问能力。作为主要特点，WEbcoli 系统提供了用户友好的丰富网络界面，允许用户虚拟设计和合成源自基因组规模的野生型大肠杆菌模型的突变株，并通过图形编辑器定制感兴趣的途径。此外，基于约束的通量分析可用于量化代谢通量，并在各种遗传和/或环境条件下描述生理和代谢状态。