可溶性CD26与慢性嗜酸性粒细胞性肺炎患者的疾病严重程度呈负相关。
Soluble CD26 is inversely Associated with Disease Severity in Patients with Chronic Eosinophilic Pneumonia.
作者信息
Matsuno Osamu, Miyazaki Eishi, Nureki Shinichi, Ueno Takuya, Ando Masaru, Kumamoto Toshihide
机构信息
Division of Respiratory Disease, Department of Brain and Nerve Science, Oita University Faculty of Medicine, Ufu-city, Oita 879-5593, Japan.
出版信息
Biomark Insights. 2007 Feb 7;1:201-4.
BACKGROUNDS
CD26, a multifunctional T cell surface glycoprotein, is a type II transmembrane protein containing only six amino acid residues in its cytoplasmic region. In addition to its membrane form, CD26 exists in plasma in a soluble form (sCD26), which is thought to be the extracellular domain of the molecule cleaved from the cell surface. Recent studies indicated CD26 have an important role in the pathogenesis of asthma, known as Th2 like disease. The function of CD26 in the esosinophlic lung disease is not well understood.
METHODS
Serum sCD26 was determined by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia, chronic eosinophilic pneumonia (CEP), and sarcoidosis, and in healthy volunteers, to establish its value for discriminating between disease entities and as marker of disease activity.
RESULTS
Soluble CD26 was significantly reduced in CEP and was related to disease severity. In particular, sCD26 was inversely correlated with arterial oxygen tension in CEP.
CONCLUSION
Serum levels of sCD26 might appear to be useful as a new marker of CEP disease activity.
背景
CD26是一种多功能T细胞表面糖蛋白，为II型跨膜蛋白，其胞质区仅含六个氨基酸残基。除膜形式外，CD26还以可溶性形式（sCD26）存在于血浆中，该可溶性形式被认为是从细胞表面裂解下来的分子胞外结构域。最近的研究表明，CD26在哮喘（一种类似Th2型疾病）的发病机制中起重要作用。CD26在嗜酸性粒细胞性肺病中的功能尚不清楚。
方法
采用酶联免疫吸附测定法测定急性嗜酸性粒细胞性肺炎、慢性嗜酸性粒细胞性肺炎（CEP）、结节病患者及健康志愿者血清中的sCD26，以确定其在区分疾病实体和作为疾病活动标志物方面的价值。
结果
CEP患者可溶性CD26显著降低，且与疾病严重程度相关。特别是，CEP患者的sCD26与动脉血氧分压呈负相关。
结论
血清sCD26水平可能是CEP疾病活动的一种有用新标志物。
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