Department of Geriatric and Gerontology, Department of Endocrinology and Metabolism and Department of Urology, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brazil.
Clinics (Sao Paulo). 2009;64(8):781-4. doi: 10.1590/S1807-59322009000800012.
Testosterone is needed for normal male development, muscle strength, bone mineralization, hematopoietic function, and sexual and reproductive functions. The main purpose of androgen deprivation therapy in prostate cancer is to reduce tumor progression, but therapy is often accompanied by significant adverse effects.
This study aimed to determine the effects of androgen deprivation therapy on body composition and resting metabolic rate in patients with prostate cancer.
A prospective study was performed to evaluate the body composition of 16 elderly males (aged 63-96; median age 71) with prostate cancer scheduled for orchiectomy, one year before and after surgery. Body composition was measured by DEXA, and energy expenditure, fat and carbohydrate oxidation were measured by indirect calorimetry.
Body weight (p=0.01), lean mass (p=0.004), and lipid oxidation (p=0.001) decreased significantly. Carbohydrate oxidation (p=0.02), FSH (p=0.0001) and LH (p=0.0001) levels increased significantly. Changes in fat mass (p=0.06) and bone mineral density (p=0.48) were not significant.
After 12 months of androgen deprivation therapy, elderly men with metastatic prostate cancer exhibit a decline in lean body mass and lipid oxidation, together with increased carbohydrate oxidation.
睾丸激素对于男性的正常发育、肌肉力量、骨矿化、造血功能以及性和生殖功能至关重要。前列腺癌患者进行雄激素剥夺治疗的主要目的是降低肿瘤进展速度，但治疗通常伴随着显著的不良反应。
本研究旨在确定雄激素剥夺治疗对前列腺癌患者身体成分和静息代谢率的影响。
前瞻性研究评估了 16 名老年男性（年龄 63-96 岁；中位年龄 71 岁）的身体成分，这些男性患有前列腺癌，计划接受睾丸切除术，在手术前一年和手术后一年进行评估。身体成分通过 DEXA 进行测量，能量消耗、脂肪和碳水化合物氧化通过间接测热法进行测量。
体重（p=0.01）、瘦体重（p=0.004）和脂质氧化（p=0.001）显著下降。碳水化合物氧化（p=0.02）、FSH（p=0.0001）和 LH（p=0.0001）水平显著升高。脂肪量（p=0.06）和骨密度（p=0.48）的变化不显著。
在接受雄激素剥夺治疗 12 个月后，患有转移性前列腺癌的老年男性表现出瘦体重和脂质氧化减少，同时碳水化合物氧化增加。
