Schneider R, Heverhagen A E, Moll R, Bartsch D K, Schlosser K
Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Germany.
Exp Clin Endocrinol Diabetes. 2010 Aug;118(8):520-3. doi: 10.1055/s-0029-1231083. Epub 2009 Aug 18.
Although elevated blood levels of calcitonin are considered highly indicative for the presence of medullary thyroid carcinomas, they may be observed in patients with chronic kidney disease or in consequence of ectopic calcitonin production. We report two patients who presented with excessively elevated calcitonin levels. Diagnostic work-up revealed a single thyroid nodule and a pancreatic tumor with ectopic calcitonin secretion in both of them. On the basis of these case reports, the diagnostic work flow and management in case of clearly elevated calcitonin levels are described and discussed.
尽管血液中降钙素水平升高被认为是甲状腺髓样癌存在的高度指示，但在慢性肾病患者或由于异位降钙素产生的情况下也可能观察到这种情况。我们报告了两名降钙素水平异常升高的患者。诊断检查发现他们两人均有一个甲状腺结节和一个分泌异位降钙素的胰腺肿瘤。基于这些病例报告，描述并讨论了降钙素水平明显升高情况下的诊断流程和管理。
