用于免疫功能低下患者耶氏肺孢子菌肺炎推定诊断的（1,3）-β-D-葡聚糖检测的临床评估
Clinical evaluation of a (1,3)-beta-D-glucan assay for presumptive diagnosis of Pneumocystis jiroveci pneumonia in immunocompromised patients.
作者信息
Del Bono Valerio, Mularoni Alessandra, Furfaro Elisa, Delfino Emanuele, Rosasco Lorenzo, Miletich Franca, Viscoli Claudio
机构信息
Clinica Malattie Infettive, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy.
出版信息
Clin Vaccine Immunol. 2009 Oct;16(10):1524-6. doi: 10.1128/CVI.00276-09. Epub 2009 Aug 19.
Abstract
(1,3)-beta-d-Glucan (BG) is a component of the Pneumocystis jiroveci cell wall. Thirty-one immunocompromised patients with pneumonia (16 with presumptive pneumocystis pneumonia [PCP] and 15 with non-PCP) were evaluated for serum BG levels. Serum from all 16 presumptive PCP patients and from 2/15 patients with non-PCP was positive for BG. Results indicate that BG is a reliable marker for diagnosing PCP.
摘要
（1,3）-β-D-葡聚糖（BG）是耶氏肺孢子菌细胞壁的一个组成部分。对31例免疫功能低下的肺炎患者（16例疑似肺孢子菌肺炎[PCP]和15例非PCP患者）的血清BG水平进行了评估。所有16例疑似PCP患者以及15例非PCP患者中的2例血清BG呈阳性。结果表明，BG是诊断PCP的可靠标志物。
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