Dixon J, Roberts F L, Tackley R M, Lewis G T, Connell H, Prys-Roberts C
Sir Humphry Davy Department of Anaesthesia, University of Bristol, Bristol Royal Infirmary.
Br J Anaesth. 1990 Feb;64(2):142-7. doi: 10.1093/bja/64.2.142.
A computer-controlled infusion of propofol designed to achieve a target blood concentration of propofol 3 microgram ml-1 was used to investigate the possibility of an interaction between propofol and fentanyl in 32 patients undergoing body surface surgery. In 16 patients who were not receiving a neuromuscular blocker during maintenance anaesthesia with 67% nitrous oxide, there were no significant differences in blood concentrations of propofol between eight patients who received fentanyl 5 micrograms kg-1 before induction of anaesthesia, and eight patients who did not. In a further 16 patients who received vecuronium during maintenance anaesthesia with 67% nitrous oxide, there were no significant differences in blood propofol concentrations between eight patients who received fentanyl 5 micrograms kg-1 before induction of anaesthesia, and eight patients who did not. Fentanyl administered i.v. immediately before a computer-controlled infusion of propofol resulted in more satisfactory anaesthetic conditions than when fentanyl was not used, but did not significantly prolong the recovery time.
采用计算机控制输注丙泊酚，使其目标血药浓度达到3微克/毫升，以研究32例接受体表手术患者中丙泊酚与芬太尼之间相互作用的可能性。在16例在维持麻醉期间未接受神经肌肉阻滞剂且吸入67%氧化亚氮的患者中，麻醉诱导前接受5微克/千克芬太尼的8例患者与未接受芬太尼的8例患者之间，丙泊酚血药浓度无显著差异。在另外16例在维持麻醉期间接受维库溴铵且吸入67%氧化亚氮的患者中，麻醉诱导前接受5微克/千克芬太尼的8例患者与未接受芬太尼的8例患者之间，丙泊酚血药浓度也无显著差异。在计算机控制输注丙泊酚之前立即静脉注射芬太尼，与未使用芬太尼相比，麻醉效果更令人满意，但并未显著延长恢复时间。
