Gill S S, Wright E M, Reilly C S
Department of Anaesthesia, University of Sheffield.
Br J Anaesth. 1990 Dec;65(6):760-5. doi: 10.1093/bja/65.6.760.
The effect of pretreatment with fentanyl on the pharmacokinetics of a single bolus of propofol was studied in 17 female patients (mean age 35 yr), ASA grade I. Eight patients received fentanyl 1.5 micrograms kg-1 5 min before induction of anaesthesia. In all patients anaesthesia was induced with propofol 2.5 mg kg-1 and maintained with halothane and nitrous oxide in oxygen. Pretreatment with fentanyl resulted in prolonged apnoea in all eight patients compared with three of nine patients in the control group. The pharmacokinetic values for propofol were described by a three-compartment mammillary model with rapid distribution phases (T1/2 alpha mean (SEM) 3.1 (2.0) min and T1/2 beta 44 (9.1) min) and a slower final phase of T1/2 gamma 520 (96) min. The clearance of propofol was rapid (mean 1.6 (0.24) litre min-1). Propofol was distributed initially into a relatively large central compartment (mean 23.7 (6.6) litre) and was extensively redistributed (mean Vss 593 (157) litre). There was no difference in the pharmacokinetic profile of propofol between the two groups.
在17名美国麻醉医师协会（ASA）I级的女性患者（平均年龄35岁）中，研究了芬太尼预处理对单次注射异丙酚药代动力学的影响。8名患者在麻醉诱导前5分钟接受1.5微克/千克的芬太尼。所有患者均以2.5毫克/千克的异丙酚诱导麻醉，并以氟烷和氧化亚氮-氧气维持麻醉。与对照组9名患者中的3名相比，芬太尼预处理导致所有8名患者的呼吸暂停时间延长。异丙酚的药代动力学值由具有快速分布相（T1/2α均值（标准误）3.1（2.0）分钟和T1/2β44（9.1）分钟）和较慢终末相T1/2γ520（96）分钟的三室乳头状模型描述。异丙酚的清除率很快（平均1.6（0.24）升/分钟）。异丙酚最初分布到一个相对较大的中央室（平均23.7（6.6）升），并广泛再分布（平均稳态分布容积593（157）升）。两组之间异丙酚的药代动力学特征没有差异。
