Keso L, Salaspuro M
Research Unit of Alcohol Diseases, University Central Hospital of Helsinki, Finland.
Br J Addict. 1990 Feb;85(2):209-15. doi: 10.1111/j.1360-0443.1990.tb03073.x.
The study group consisted of 73 employed alcoholics, who were directed to inpatient treatment. They were evaluated (structured interview, GGT, and MCV) before the treatment period and 8 months after the termination of the treatment. Patients with diseases or medications influencing the laboratory tests were not included in the study group. According to the structured interview 72.6% of the patients were drinking in a controlled manner (less than 40 g/d ethanol) during the 2-month period prior to the follow-up evaluation. According to the laboratory data 52.1% of the patients had been drinking in a controlled manner (i.e. both GGT and MCV values were normal). With the interview and laboratory data combined 39.7% of the patients had been drinking in a controlled manner. Thus the drinking outcome was strongly influenced by the selection of the variables used to measure the outcome. It is recommended that no studies should be carried out about the drinking outcome of alcoholism treatment without the use of laboratory markers as a part of the evaluation.
研究组由73名在职酗酒者组成，他们被安排接受住院治疗。在治疗期之前以及治疗结束8个月后，对他们进行了评估（结构化访谈、γ-谷氨酰转移酶和平均红细胞体积）。研究组未纳入患有影响实验室检查的疾病或正在服用影响实验室检查药物的患者。根据结构化访谈，在随访评估前的2个月期间，72.6%的患者饮酒量可控（乙醇摄入量少于40克/天）。根据实验室数据，52.1%的患者饮酒量可控（即γ-谷氨酰转移酶和平均红细胞体积值均正常）。将访谈和实验室数据相结合，39.7%的患者饮酒量可控。因此，饮酒结果受到用于衡量结果的变量选择的强烈影响。建议在不使用实验室指标作为评估一部分的情况下，不应开展关于酒精中毒治疗饮酒结果的研究。
